{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:45:10Z","timestamp":1792035910928,"version":"4.4.0"},"reference-count":69,"publisher":"Wiley","issue":"32","license":[{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFB3800705"],"award-info":[{"award-number":["2021YFB3800705"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Antibiotic\u2010resistant pathogens have become a global public health crisis, especially biofilm\u2010induced refractory infections. Efficient, safe, and biofilm microenvironment (BME)\u2010adaptive therapeutic strategies are urgently demanded to combat antibiotic\u2010resistant biofilms. Here, inspired by the fascinating biological structures and functions of phages, the de novo design of a spiky Ir@Co\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    particle is proposed to serve as an artificial phage for synergistically eradicating antibiotic\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    biofilms. Benefiting from the abundant nanospikes and highly active Ir sites, the synthesized artificial phage can simultaneously achieve efficient biofilm accumulation, extracellular polymeric substance (EPS) penetration, and superior BME\u2010adaptive reactive oxygen species (ROS) generation, thus facilitating the in situ ROS delivery and enhancing the biofilm eradication. Moreover, transcriptomics found that the artificial phage obstructs the bacterial attachment to EPS, disrupts the maintenance of the BME, and fosters the dispersion and eradication of biofilms by down\u2010regulating the associated genes for the biosynthesis and preservation of both intra\u2010 and extracellular environments. The in vivo results demonstrate that the artificial phage can treat the biofilm\u2010induced recalcitrant infected wounds equivalent to vancomycin. It is suggested that the design of this spiky artificial phage with synergistic \u201cpenetrate and eradicate\u201d capability to treat antibiotic\u2010resistant biofilms offers a new pathway for bionic and nonantibiotic disinfection.\n                  <\/jats:p>","DOI":"10.1002\/adma.202404411","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T05:09:00Z","timestamp":1717564140000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Artificial Phages with Biocatalytic Spikes for Synergistically Eradicating Antibiotic\u2010Resistant Biofilms"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6050-8039","authenticated-orcid":false,"given":"Sutong","family":"Xiao","sequence":"first","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Department of Medical Ultrasound West China 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