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Here, it is shown that black phosphorus nanosheets (BPNSs) interact directly with \u03b1\u2010syn fibrils to trigger their disaggregation for PD treatment. Moreover, BPNSs have a specific affinity for \u03b1\u2010syn through van der Waals forces. And BPNSs are found to activate autophagy to maintain \u03b1\u2010syn homeostasis, improve mitochondrial dysfunction, reduce reactive oxygen species levels, and rescue neuronal death and synaptic loss in PC12 cells. It is also observed that BPNSs penetrate the blood\u2013brain barrier and protect against dopamine neuron loss, alleviating behavioral disorders in 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine (MPTP) induced mouse model and hA53T \u03b1\u2010syn transgenic mice. Together, the study reveals that BPNSs have the potential as a novel integrated nanomedicine for clinical diagnosis and treatment of neurological diseases.<\/jats:p>","DOI":"10.1002\/adma.202404576","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T12:10:51Z","timestamp":1714651851000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Black Phosphorus Nanosheets Protect Neurons by Degrading Aggregative \u03b1\u2010syn and Clearing ROS in Parkinson's Disease"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9610-4271","authenticated-orcid":false,"given":"Meina","family":"He","sequence":"first","affiliation":[{"name":"Engineering Research Center for Molecular Medicine College of Basic Medical Science Guizhou Medical University  Guiyang 561113 China"},{"name":"Department of Biology College of Basic Medical Science Guizhou Medical University  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