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The efficacy of cuproptosis is highly dependent on intracellular copper accumulation and counteracted by a high level of glutathione (GSH) in tumor cells. Here, this work develops a self\u2010amplified cuproptosis nanoparticles (Cel\u2010Cu NP) using celastrol (Cel), a natural product isolated from medical plant. In Cel\u2010Cu NP, Cel serves as a versatile copper ionophore, exhibiting an ideal coordination capacity toward copper ions without compromising the cuproptosis induction. Notably, Cel can simultaneously scavenge GSH content to amplify cuproptosis. Moreover, this self\u2010amplified cuproptosis further activates immunogenic cell death (ICD) to elicit robust immune response. Combining with immune checkpoint blockade, Cel\u2010Cu NP effectively eradicates metastatic tumors in a mouse lung metastasis model. This study provides an efficient nanomedicine by inducing self\u2010amplified cuproptosis for robust immunotherapy.<\/jats:p>","DOI":"10.1002\/adma.202404971","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T17:26:59Z","timestamp":1719509219000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":230,"title":["Glutathione\u2010Scavenging Celastrol\u2010Cu Nanoparticles Induce Self\u2010Amplified Cuproptosis for Augmented Cancer Immunotherapy"],"prefix":"10.1002","volume":"36","author":[{"given":"Sheng","family":"Lu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Organic\u2010Inorganic Composites Beijing Laboratory of Biomedical Materials College of Life Science and Technology Beijing University of Chemical Technology  Beijing 100029 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