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A poly(ethylene glycol) (PEG) and poly(\u03b5\u2010caprolactone) (PCL) multi\u2010block copolymer basing polyurethane (PCEU) is synthesized and fabricated into blank microspheres (BMs). The microspheres are elastic in compression test. A clinical contrast agent lipiodol is encapsulated in the microspheres to receive fusible radiopaque microspheres (FRMs). The sizes of FRMs are uniform and range from 142.2 to 343.1\u00a0\u00b5m. The encapsulated lipiodol acts as the plasticizer to reduce the melting temperature point (<jats:italic>T<\/jats:italic><jats:sub>m<\/jats:sub>) of PECU microspheres, thus, leading to the fusion of microspheres to exhibit efficient embolization in vivo. The performance of FRMs is carried out on a rabbit ear embolization model. Serious ischemic necrosis is observed and the radiopacity of FRMs sustains much longer time than that of commercial contrast agent Loversol in vivo. The fusible and radiopaque microsphere is promising to be developed as an exciting embolic agent.<\/jats:p>","DOI":"10.1002\/adma.202405224","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T03:51:39Z","timestamp":1723175499000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Fusible and Radiopaque Microspheres for Embolization"],"prefix":"10.1002","volume":"36","author":[{"given":"Jing","family":"Li","sequence":"first","affiliation":[{"name":"National Engineering Research Center for Biomaterials College of Biomedical Engineering Sichuan University  Chengdu 610064 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Xu","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials College of Biomedical Engineering Sichuan University  Chengdu 610064 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