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In this study, hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S)\u2010evolving alternately catalytic bio\u2010heterojunction enzyme (AC\u2010BioHJzyme) consisting of CuFe\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>3<\/jats:sub>\n                    and lactate oxidase (LOD) named as CuFe\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>3<\/jats:sub>\n                    @LOD is developed. AC\u2010BioHJzyme exhibits circular enzyme\u2010mimetic antibacterial (EMA) activity and macrophage re\u2010rousing capability, which can be activated by near\u2010infrared\u2010II (NIR\u2010II) light. In this system, LOD exhausts lactate derived from bacterial anaerobic respiration and generated hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ), which provides an abundant stock for the peroxidase\u2010mimetic activity to convert the produced H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    into germicidal \u2022OH. The GPx\u2010mimetic activity endows AC\u2010BioHJzyme with a glutathione consumption property to block the antioxidant systems in bacterial metabolism, while the O\n                    <jats:sub>2<\/jats:sub>\n                    provided by the CAT\u2010mimetic activity can generate\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    under the NIR\u2010II irradiation. Synchronously, the H\n                    <jats:sub>2<\/jats:sub>\n                    S gas liberated from CuFe\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>3<\/jats:sub>\n                    @LOD under the infectious micromilieu allows the reduction of Fe(III)\/Cu(II) to Fe(II)\/Cu(\u0406), resulting in sustained circular EMA activity. In vitro and in vivo assays indicate that the CuFe\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>3<\/jats:sub>\n                    @LOD AC\u2010BioHJzyme significantly facilitates the infectious cutaneous regeneration by killing bacteria, facilitating epithelialization\/collagen deposition, promoting angiogenesis, and reprogramming macrophages. This study provides a countermeasure for deep infectious wound healing via circular enzyme\u2010mimetic antibiosis and macrophage re\u2010rousing.\n                  <\/jats:p>","DOI":"10.1002\/adma.202405659","type":"journal-article","created":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T03:59:00Z","timestamp":1719633540000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["A H\u2082S\u2010Evolving Alternately\u2010Catalytic Enzyme Bio\u2010Heterojunction with Antibacterial and Macrophage\u2010Reprogramming Activity for All\u2010Stage Infectious Wound Regeneration"],"prefix":"10.1002","volume":"36","author":[{"given":"Miaomiao","family":"He","sequence":"first","affiliation":[{"name":"College of Biomedical Engineering School of Chemical Engineering Sichuan University  Chengdu 610065 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