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Phototherapy represents a promising alternative to antibiotics in combating <jats:italic>M.tb<\/jats:italic>. Exploring an intelligent material allowing effective tuberculosis treatment is definitely appealing, yet a significantly challenging task. Herein, an all\u2010in\u2010one biomimetic therapeutic nanoparticle featured by aggregation\u2010induced second near\u2010infrared emission, granuloma\u2010targeting, and self\u2010oxygenation is constructed, which can serve for prominent fluorescence imaging\u2010navigated combined phototherapy toward tuberculosis. After camouflaging the biomimetic erythrocyte membrane, the nanoparticles show significantly prolonged blood circulation and increased selective accumulation in tuberculosis granuloma. Upon laser irradiation, the loading photosensitizer of aggregation\u2010induced emission photosensitizer elevates the production of reactive oxygen species (ROS), causing <jats:italic>M.tb<\/jats:italic> damage and death. The delivery of oxygen to relieve the hypoxic granuloma microenvironment supports ROS generation during photodynamic therapy. Meanwhile, the photothermal agent, Prussian blue nanoparticles, plays the role of good photothermal killing effect on <jats:italic>M.tb<\/jats:italic>. Moreover, the growth and proliferation of granuloma and <jats:italic>M.tb<\/jats:italic> colonies are effectively inhibited in the nanoparticle\u2010treated tuberculous granuloma model mice, suggesting the combined therapeutic effects of enhancing photodynamic therapy and photothermal therapy.<\/jats:p>","DOI":"10.1002\/adma.202406143","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T01:29:33Z","timestamp":1722216573000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["NIR\u2010II AIE Luminogen\u2010Based Erythrocyte\u2010Like Nanoparticles with Granuloma\u2010Targeting and Self\u2010Oxygenation Characteristics for Combined Phototherapy of Tuberculosis"],"prefix":"10.1002","volume":"36","author":[{"given":"Huanhuan","family":"Wang","sequence":"first","affiliation":[{"name":"The Seventh Affiliated Hospital Southern Medical University  Foshan Guangdong 528200 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