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Here, the study presents a flexible and ultrathin self\u2010sustainable bioelectronic patch (Bio\u2010patch), which can self\u2010adhere to the lesion area of organs and generate bionic electrical signals synchronized vagal nerve envelope in situ to implement Bio\u2010ES. It allows adaptive adjustment of intensity, frequency, and waveform of the Bio\u2010ES to fully meet personalized needs of tissue regeneration based on real\u2010time feedback from the vagal neural controlled organs. With this foundation, the Bio\u2010patch can effectively intervene with excessive fibrosis and microvascular stasis during the natural healing process by regulating the polarization time of macrophages, promoting the reconstruction of the tissue\u2010engineered structure, and accelerating the repair of damaged liver and kidney. This work develops a practical approach to realize biomimetic electronic modulation of the growth and development of soft organs only using a multifunctional Bio\u2010patch, which establishes a new paradigm for precise bioelectronic medicine.<\/jats:p>","DOI":"10.1002\/adma.202406636","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T23:55:54Z","timestamp":1723766154000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Self\u2010Adhesive and Self\u2010Sustainable Bioelectronic Patch for Physiological Feedback Electronic Modulation of Soft Organs"],"prefix":"10.1002","volume":"36","author":[{"given":"Lili","family":"Qian","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Nanjing University of Science and Technology  Nanjing 210094 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