{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:06:23Z","timestamp":1790255183327,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"44","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A regenerative peripheral nerve interface (RPNI) offers a therapeutic solution for nerve injury through reconstruction of the target muscle. However, implanting a transected peripheral nerve into an autologous skeletal muscle graft in RPNI causes donor\u2010site morbidity, highlighting the need for tissue\u2010engineered skeletal muscle constructs. Here, an engineered regenerative isolated peripheral nerve interface (eRIPEN) is developed using 3D skeletal cell printing combined with direct electrospinning to create a nanofiber membrane envelop for host nerve implantation. In this in vivo study, after over 8 months of RPNI surgery, the eRIPEN exhibits a minimum Feret diameter of 15\u201320\u00a0\u00b5m with a cross\u2010sectional area of 100\u2013500 \u00b5m\n                    <jats:sup>2<\/jats:sup>\n                    , representing the largest distribution of myofibers. Furthermore, neuromuscular junction formation and muscle contraction with a force of \u224828 N are observed. Notably, the decreased hypersensitivity to mechanical\/thermal stimuli and an improved tibial functional index from \u221277 to \u221256 are found in the eRIPEN group. The present novel concept of eRIPEN paves the way for the utilization and application of tissue\u2010engineered constructs in RPNI, ultimately realizing neuroprosthesis control through synaptic connections.\n                  <\/jats:p>","DOI":"10.1002\/adma.202406652","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T06:55:25Z","timestamp":1721890525000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Engineered Regenerative Isolated Peripheral Nerve Interface for Targeted Reinnervation"],"prefix":"10.1002","volume":"36","author":[{"given":"Jinju","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Health Science Graduate School Korea University  145 Anam\u2010ro, Seongbuk\u2010gu Seoul 02841 Republic of Korea"},{"name":"Transdisciplinary Major in Learning Health Systems Department of Healthcare Sciences Graduate School Korea University  145 Anam\u2010ro, Seongbuk\u2010gu Seoul 02841 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seongsu","family":"Eom","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Pohang University of Science and Technology (POSTECH)  77 Cheongam\u2010ro, Nam\u2010gu Pohang Gyeongbuk 37673 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Sik","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Pohang University of Science and Technology (POSTECH)  77 Cheongam\u2010ro, Nam\u2010gu Pohang Gyeongbuk 37673 Republic of Korea"},{"name":"POSTECH\u2010Catholic Biomedical Engineering Institute POSTECH  Pohang Gyeongbuk 37673 Republic of 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