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Simply killing drug\u2010resistant pathogens cannot effectively eliminate their threat since the drug\u2010resistant genes (DRGs) released from dead drug\u2010resistant pathogens are difficult to eliminate and can further spread via horizontal gene transfer, leading to the spread of drug resistance. The development of antibacterial materials with sterilization and DRGs cleavage activities is highly crucial. Herein, a living system, Ce\u2010PEA@<jats:italic>Bdello<\/jats:italic>, is fabricated with bacterial killing and DRGs cleavage activities for blocking bacterial drug resistance dissemination by engineered <jats:italic>Bdellovibrio bacteriovorus<\/jats:italic> (<jats:italic>Bdello<\/jats:italic>). Ce\u2010PEA@<jats:italic>Bdello<\/jats:italic> is obtained by engineering <jats:italic>Bdello<\/jats:italic> with dopamine and a multinuclear cerium (IV) complex. Ce\u2010PEA@<jats:italic>Bdello<\/jats:italic> can penetrate and eliminate kanamycin\u2010resistant <jats:italic>P. aeruginosa<\/jats:italic> (Kan<jats:sup>R<\/jats:sup>) biofilms via the synergistic effect of predatory <jats:italic>Bdello<\/jats:italic> and photothermal polydopamine under near\u2010infrared light. Additionally, the DNase\u2010mimicking ability of Ce\u2010PEA@<jats:italic>Bdello<\/jats:italic> endows it with genome and plasmid DNA cleavage ability. An in vivo study reveals that Ce\u2010PEA@<jats:italic>Bdello<\/jats:italic> can eliminate <jats:italic>P. aeruginosa<\/jats:italic> (Kan<jats:sup>R<\/jats:sup>) and cleave DRGs in scald\/burn infected wounds to block the spread of drug resistance and accelerate wound healing. This bioactive system constructed from natural living materials offers a promising means for blocking the spread of drug resistance.<\/jats:p>","DOI":"10.1002\/adma.202406910","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T02:50:37Z","timestamp":1723603837000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["A Strategy of Killing Two Birds With One Stone for Blocking Drug Resistance Spread With Engineered <i>Bdellovibrio bacteriovorus<\/i>"],"prefix":"10.1002","volume":"36","author":[{"given":"Yu","family":"Rao","sequence":"first","affiliation":[{"name":"Jiangsu Engineering Laboratory of Novel Functional Polymeric Materials Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Suzhou Key Laboratory of Soft Material and New Energy Key Laboratory of Polymeric Materials Design and Synthesis for Biomedical Function College of Chemistry Chemical Engineering and Materials Science Soochow University  Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Engineering Laboratory of Novel Functional Polymeric Materials Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Suzhou Key Laboratory of Soft Material and New Energy Key Laboratory of Polymeric Materials Design and Synthesis for Biomedical Function College of Chemistry Chemical Engineering and Materials Science Soochow University  Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangsu Engineering Laboratory of Novel Functional Polymeric Materials Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Suzhou Key Laboratory of Soft Material and New Energy Key Laboratory of Polymeric Materials Design and Synthesis for Biomedical Function College of Chemistry Chemical Engineering and Materials Science Soochow University  Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichen","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Engineering Laboratory of Novel Functional Polymeric Materials Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Suzhou Key Laboratory of Soft Material and New Energy Key Laboratory of Polymeric Materials Design and Synthesis for Biomedical Function College of Chemistry Chemical Engineering and Materials Science Soochow University  Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingxiang","family":"He","sequence":"additional","affiliation":[{"name":"Jiangsu Engineering Laboratory of Novel Functional Polymeric Materials Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Suzhou Key Laboratory of Soft Material and New Energy Key Laboratory of Polymeric Materials Design and Synthesis for Biomedical Function College of Chemistry Chemical Engineering and Materials Science Soochow University  Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaonan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Jiangsu Engineering Laboratory of Novel Functional Polymeric Materials Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Suzhou Key Laboratory of Soft Material and New Energy Key Laboratory of Polymeric Materials Design and Synthesis for Biomedical Function College of Chemistry Chemical Engineering and Materials Science Soochow University  Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangna","family":"Guo","sequence":"additional","affiliation":[{"name":"Jiangsu Engineering Laboratory of Novel Functional Polymeric Materials Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Suzhou Key Laboratory of Soft Material and New Energy Key Laboratory of Polymeric Materials Design and Synthesis for Biomedical Function College of Chemistry Chemical Engineering and Materials Science Soochow University  Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7799-4961","authenticated-orcid":false,"given":"Hong","family":"Chen","sequence":"additional","affiliation":[{"name":"Jiangsu Engineering Laboratory of Novel Functional Polymeric Materials Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Suzhou Key Laboratory of Soft Material and New Energy Key Laboratory of Polymeric Materials Design and Synthesis for Biomedical Function College of Chemistry Chemical Engineering and Materials Science Soochow University  Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,13]]},"reference":[{"key":"e_1_2_8_1_1","first-page":"170","volume":"21","author":"Mullard A.","year":"2022","journal-title":"Nat. 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