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Herein, a hierarchically organized membrane is developed that mimics the heterogeneous anatomy and properties of the natural enthesis and finely facilitates the reconstruction of tendon\u2013bone interface. A biphasic membrane consisting of a microporous layer and a mineralized fibrous layer is constructed through the non\u2010solvent induced phase separation (NIPS) strategy followed by a co\u2010axial electrospinning procedure. Cationic kartogenin (KGN)\u2010conjugated nanogel (nGel\u2010KGN) and osteo\u2010promotive struvite are incorporated within the membranes in a region\u2010specific manner. During in vivo repair, the nGel\u2010KGN\u2010functionalized microporous layer is adjacent to the tendon which intends to suppress scar tissue formation at the lesion and simultaneously heightens chondrogenesis. Meanwhile, the struvite\u2010containing fibrous layer covers the tubercula minus to enhance stem cell aggregation and bony ingrowth. Such tissue\u2010specific features and spatiotemporal release behaviors contribute to effective guidance of specific defect\u2010healing events at the transitional region, further leading to the remarkably promoted regenerative outcome in terms of the fibrocartilaginous tissue formation, collagen fiber alignment, and optimized functional motion of rotator cuff. These findings render a novel biomimetic membrane as a promising material for clinical rotator cuff repair.<\/jats:p>","DOI":"10.1002\/adma.202407358","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T06:42:22Z","timestamp":1738305742000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Tissue Mimetic Membranes for Healing Augmentation of Tendon\u2013Bone Interface in Rotator Cuff Repair"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8515-2673","authenticated-orcid":false,"given":"Yuwei","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Chemistry The Chinese University of Hong Kong  Shatin, N. T. 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