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Complex coacervation emerges as an intriguing strategy for designing functional nanoreactors. In this study, a noteworthy achievement is presented in the development of lactobionic acid\u2010modified tumor microenvironment (TME)\u2010responsive polyelectrolyte complex vesicles (HGS\u2010PCVs) based on bioinspired homopolypeptoids, which serve as a facile, intelligent, and highly efficient nanoreactor tunable for glucose oxidase, hemoglobin,\u00a0and sorafenib (SRF) to hepatic cancer cells. The TME\u2010responsive permeability of HGS\u2010PCVs enables the selective entry of glucose into their interior, triggering an enzymatic cascade reaction within the tumor. This intricate process generates toxic hydroxyl radicals while concurrently lowering the pH. Consequently, this pH shift enhances the SRF release, effectively promoting ferroptosis and apoptosis in the target cancer cells. Further, the administration of the HGS\u2010PCVs not only initiates immunogenic cell death but also plays a crucial role in inducing the maturation of dendritic cells within lymph nodes. It stimulates an adaptive T\u2010cell response, a crucial mechanism that contributes to impeding the growth of distant tumors in vivo, demonstrating the promising potential of PCVs for cancer immunotherapy.<\/jats:p>","DOI":"10.1002\/adma.202407378","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T11:19:54Z","timestamp":1725535194000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Coacervation\u2010Driven Semipermeable Nanoreactors for Enzymatic Cascade\u2010Mediated Cancer Combination Therapy with Enhanced Efficacy"],"prefix":"10.1002","volume":"36","author":[{"given":"Min","family":"Lin","sequence":"first","affiliation":[{"name":"State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University  Changchun Jilin 130012 P. R. 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