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While metallo\u2010immunotherapy is a promising strategy that can activate the antitumor immunity, its role in promoting CAR\u2010T cell therapy remains elusive. The first single\u2010element nanomaterial based on chromium nanoparticles (Cr NPs) for cancer photo\u2010metallo\u2010immunotherapy has been reported previously. Herein, an extended study using biodegradable polydopamine as a versatile carrier for these nanoparticles, enabling synergistic CAR\u2010T cell therapy, is reported. The results show that these nanocomposites with or without further encapsulation of the anticancer drug alpelisib can promote the CAR\u2010T cell migration and antitumor effect. Upon irradiation with near\u2010infrared light, they caused mild hyperthermia that can \u201cwarm\u201d the \u201ccold\u201d tumor microenvironment (TME). The administration of B7\u2010H3 CAR\u2010T cells to NOD severe combined immunodeficiency gamma mice bearing a human hepatoma or PIK3CA\u2010mutated breast tumor can significantly inhibit the tumor growth after the induction of tumor hyperthermia by the nanocomposites and promote the secretion of serum cytokines, including IL\u20102, IFN\u2010\u03b3, and TNF\u2010\u03b1. The trivalent Cr\n                    <jats:sup>3+<\/jats:sup>\n                    ions, which are the major degradation product of these nanocomposites, can increase the CXCL13 and CCL3 chemokine expressions to generate tertiary lymphoid structures (TLSs) in the tumor tissues, facilitating the CAR\u2010T cell infiltration.\n                  <\/jats:p>","DOI":"10.1002\/adma.202407425","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T07:35:40Z","timestamp":1718868940000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Photo\u2010metallo\u2010immunotherapy: Fabricating Chromium\u2010Based Nanocomposites to Enhance CAR\u2010T Cell Infiltration and Cytotoxicity against Solid Tumors"],"prefix":"10.1002","volume":"37","author":[{"given":"Qingshuang","family":"Zou","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Huazhong University of Science and Technology Union Shenzhen Hospital (Nanshan Hospital) Shenzhen University  Shenzhen 518052 China"},{"name":"Department of Chemistry The Chinese University of Hong Kong  Shatin, N.T. Hong Kong 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Huazhong University of Science and Technology Union Shenzhen Hospital (Nanshan Hospital) Shenzhen University  Shenzhen 518052 China"},{"name":"Institute of Pharmacy and Pharmacology School of Pharmaceutical Science Hengyang Medical School University of South China  Hengyang Hunan 421001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangchao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Guangdong Second Provincial General Hospital of Jinan University  Guangzhou 510317 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Huazhong University of Science and Technology Union Shenzhen Hospital (Nanshan Hospital) Shenzhen University  Shenzhen 518052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongwei","family":"Zheng","sequence":"additional","affiliation":[{"name":"Research and Development Department Guangzhou Bio\u2010Gene Technology Co. Ltd.  Guangzhou 510530 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Huazhong University of Science and Technology Union Shenzhen Hospital (Nanshan Hospital) Shenzhen University  Shenzhen 518052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Luo","sequence":"additional","affiliation":[{"name":"Research and Development Department Guangzhou Bio\u2010Gene Technology Co. Ltd.  Guangzhou 510530 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn Y.","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Chemistry The Chinese University of Hong Kong  Shatin, N.T. Hong Kong 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanqing","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Chemistry The Chinese University of Hong Kong  Shatin, N.T. Hong Kong 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry The Chinese University of Hong Kong  Shatin, N.T. Hong Kong 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Huazhong University of Science and Technology Union Shenzhen Hospital (Nanshan Hospital) Shenzhen University  Shenzhen 518052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dixian","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Huazhong University of Science and Technology Union Shenzhen Hospital (Nanshan Hospital) Shenzhen University  Shenzhen 518052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9087-960X","authenticated-orcid":false,"given":"Dennis K. P.","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Chemistry The Chinese University of Hong Kong  Shatin, N.T. 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