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Estrogen therapy gains unsatisfactory outcomes. In this study, an artificial mucus based on dopamine (L\u2010DOPA)\u2010modified hyaluronic acid combining phytoestrogen cajaninstilbene acid and rat urinary exosomes (CUEHD) is constructed for TE treatment using a rat TE model. In the rat TE model, the dominant elastic behavior and adhesive properties of CUEHD guarantee adequate retention, rendering superior synergistic treatment efficacy and favorable biosafety characteristics. CUEHD treatment significantly increases endometrial thickness and promotes receptivity and fertility. Mechanistically, estrogen homeostasis, inflammation inhibition, and endometrial regeneration are achieved through the crosstalk between ER\u2010NLRP3\u2010IL1\u03b2 and Wnt\u2010\u03b2 catenin\u2010TGF\u03b2\u2010smad signaling pathways. 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