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However, recording neurons under vigorous activities remains a long\u2010standing challenge because it leads to intense brain deformation. Thus, three key requirements are needed simultaneously for neural devices, that is, low modulus, low specific interfacial impedance, and high electrical conductivity, to realize stable device\/brain interfaces and high\u2010quality transmission of neural signals. However, they always contradict each other in current material strategies. Here, a soft fiber neural device capable of stably tracking individual neurons in the deep brain of medium\u2010sized animals under vigorous activity is reported. Inspired by the axon architecture, this fiber neural device is constructed with a conductive gel fiber possessing a network\u2010in\u2010liquid structure using conjugated polymers and liquid matrices and then insulated with soft fluorine rubber. This strategy reconciles the contradictions and simultaneously confers the fiber neural device with low modulus (300\u00a0kPa), low specific impedance (579\u00a0k\u03a9\u00a0\u00b5m\n                    <jats:sup>2<\/jats:sup>\n                    ), and high electrical conductivity (32\u00a0700\u00a0S\u00a0m\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) \u2013 \u22481\u20133 times higher than hydrogels. Stable single\u2010unit spike tracking in running cats, which promises new opportunities for neuroscience is demonstrated.\n                  <\/jats:p>","DOI":"10.1002\/adma.202407874","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T01:31:17Z","timestamp":1721957477000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["A Soft\u2010Fiber Bioelectronic Device with Axon\u2010Like Architecture Enables Reliable Neural Recording In Vivo under Vigorous Activities"],"prefix":"10.1002","volume":"36","author":[{"given":"Chengqiang","family":"Tang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science Institute of Fiber Materials and Devices and Laboratory of Advanced Materials Fudan University  Shanghai 200438 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