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Unlike the conventional \u201cone\u2010size\u2010fits\u2010all\u201d approach, this protocol offers an option for more precise and efficacious treatment. To simulate a customized corneal crosslinking technique, four distinct microneedle (MN) molds designs, including circular, semi\u2010circular, annular and butterfly shaped, are crafted for loading an optimized RF\u2010hyaluronic acid solution and for the subsequent fabrication of MN arrays with varying morphologies. These MNs can gently puncture the corneal epithelium while preserving the integrity of the underlying stromal layer. Following the application of these microneedles, RF solution is replenished to enhance the RF content within the stroma through the punctures created by the MNs, resulting in exceptional customized corneal cross\u2010linking effects that are comparable to the conventional epi\u2010off CXL protocol. Additionally, it flattened the corneal curvature within the treated zone and facilitated rapid postoperative recovery of corneal tissue. These findings suggest that the integration of customized microneedle RF delivery with corneal crosslinking technology represents a potential novel treatment modality, holding promise for the tailored treatment of corneal pathologies, and offering a more precise and efficient alternative to traditional methods.<\/jats:p>","DOI":"10.1002\/adma.202408136","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T04:19:07Z","timestamp":1725855547000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Customized Corneal Cross\u2010Linking with Microneedle\u2010Mediated Riboflavin Delivery for Keratoconus Treatment"],"prefix":"10.1002","volume":"36","author":[{"given":"Mei","family":"Yang","sequence":"first","affiliation":[{"name":"Eye Institute and Department of Ophthalmology Eye &amp; ENT Hospital NHC Key laboratory of Myopia and Related Eye Diseases Key Laboratory of Myopia and Related Eye Diseases Chinese Academy of Medical Sciences Shanghai Research Center of Ophthalmology and Optometry Fudan University  Shanghai 200030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxian","family":"Pan","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology Eye &amp; 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