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Presently, mechano\u2013bactericidal systems, which combine distinct topological geometries with mechanical forces to physically induce bacterial apoptosis, show promising potential. However, the physical interaction process between current mechano\u2013bactericidal systems and bacteria is generally based on passive diffusion or Brownian motion and lacks the force required for biofilm penetration; thus, featuring low antibacterial efficacy. Here, a biomimetic mechano\u2013bactericidal nanomotor (VMSNT) is synthesized by functionalizing COOH\u2010PEG\u2010phenylboronic acid (PBA) on virus\u2010like mesoporous silica, with subsequent partial coating of Au caps. Enhanced by self\u2010thermophoresis capabilities and virus\u2010like topological shapes, VMSNT significantly improves mechanical antibacterial effects and biofilm penetration. In addition, scanning electron microscope (SEM) and confocal laser scanning microscope (CLSM)\u00a0analyses demonstrate that VMSNT can precisely target bacteria within the infection microenvironment, facilitated by PBA's ability to recognize and bind to the peptidoglycan on bacterial surfaces. Remarkably, VMSNT is also effective in eliminating MDR bacteria and reducing inflammation in mice models of methicillin\u2010resistant <jats:italic>Staphylococcus aureus (MRSA)<\/jats:italic>\u2010infected keratitis and endophthalmitis, with minimal adverse effects. Overall, such a nanomotor presents a promising approach for addressing the challenges of ocular MDR bacterial infections.<\/jats:p>","DOI":"10.1002\/adma.202408221","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T01:43:53Z","timestamp":1736819033000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["A Bioinspired Virus\u2010Like Mechano\u2013Bactericidal Nanomotor for Ocular Multidrug\u2010Resistant Bacterial Infection Treatment"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9809-1112","authenticated-orcid":false,"given":"Hengrui","family":"Zhang","sequence":"first","affiliation":[{"name":"Eye Institute of Shandong First Medical University State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases School of Ophthalmology, Shandong First Medical University  Qingdao 266071 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dewei","family":"Li","sequence":"additional","affiliation":[{"name":"Eye Institute of Shandong First Medical University State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases School of Ophthalmology, Shandong First Medical University  Qingdao 266071 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifang","family":"Ren","sequence":"additional","affiliation":[{"name":"Eye Institute of Shandong First Medical University State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases School of Ophthalmology, Shandong First Medical University  Qingdao 266071 P. R. 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