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However, the practical applications of sonosensitizers are hindered by their low efficacy in killing cancer cells and activating immune responses. Here, two US Food and Drug Administration\u2010approved drug ligands (ferricyanide and nitroprusside) and two types of metals (copper\/iron) are selected to construct a bimetal\u2010biligand framework (Cu[PBA\u2010NO]). Through elaborate regulation of multiple metal\/ligand coordination, the systemically administered Cu[PBA\u2010NO] nanoagent shows sono\u2010catalytic and NO release ability under ultrasound irradiation, which can be used for effective sono\u2010immunotherapy. Moreover, Cu[PBA\u2010NO] can downregulate intracellular glutathione levels that would destroy intracellular redox homeostasis and facilitate reactive oxygen species accumulation. The released tumor\u2010associated antigens subsequently facilitate dendritic cell maturation within the tumor\u2010draining lymph node, effectively initiating a T cell\u2010mediated immune response and thereby bolstering the capacity to identify and combat cancer cells. This study paves a new avenue for the efficient cancer sono\u2010immunotherapy.<\/jats:p>","DOI":"10.1002\/adma.202408242","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T08:27:33Z","timestamp":1725352053000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Bimetal\u2010Biligand Frameworks for Spatiotemporal Nitric Oxide\u2010Enhanced Sono\u2010Immunotherapy"],"prefix":"10.1002","volume":"36","author":[{"given":"Yu","family":"Cheng","sequence":"first","affiliation":[{"name":"School of Chemistry Chemical Engineering and Biotechnology Nanyang Technological University  Singapore 637371 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Zhong","sequence":"additional","affiliation":[{"name":"School of Chemistry Chemical Engineering and Biotechnology Nanyang Technological University  Singapore 637371 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