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To address this challenge, a comprehensive strategy with highly effective and integrated antimicrobial, anti\u2010inflammatory, and accelerated angiogenesis will offer a new pathway to the rapid healing of infected diabetic ulcers. Here, inspired by the tunable reactive oxygen species (ROS) regulation properties of natural peroxisomes, this work reports the design of infectious and inflammatory microenvironments self\u2010adaptive artificial peroxisomes with synergetic Co\u2010Ru pair centers (APCR) for programmed diabetic ulcer therapy. Benefiting from the synergistic Co and Ru atoms, the APCR can simultaneously achieve ROS production and metabolic inhibition for bacterial sterilization in the infectious microenvironment. After disinfection, the APCR can also eliminate ROS to alleviate oxidative stress in the inflammatory microenvironment and promote wound regeneration. The data demonstrate that the APCR combines highly effective antibacterial, anti\u2010inflammatory, and provascular regeneration capabilities, making it an efficient and safe nanomedicine for treating infectious and inflammatory diabetic foot ulcers via a programmed microenvironment self\u2010adaptive treatment pathway. This work expects that synthesizing artificial peroxisomes with microenvironments self\u2010adaptive and bifunctional enzyme\u2010like ROS regulation properties will provide a promising path to construct ROS catalytic materials for treating complex diabetic ulcers, trauma, or other infection\u2010caused diseases.<\/jats:p>","DOI":"10.1002\/adma.202408787","type":"journal-article","created":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T03:45:50Z","timestamp":1722656750000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":107,"title":["Infectious and Inflammatory Microenvironment Self\u2010Adaptive Artificial Peroxisomes with Synergetic Co\u2010Ru Pair Centers for Programmed Diabetic Ulcer Therapy"],"prefix":"10.1002","volume":"36","author":[{"given":"Yang","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Ultrasound Frontiers Science Center for Disease\u2010related Molecular Network National Clinical Research Center for Geriatrics Med\u2010X Center for Materials West China Hospital Sichuan University Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9512-756X","authenticated-orcid":false,"given":"Yuting","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Frontiers Science Center for Disease\u2010related Molecular Network National Clinical Research Center for Geriatrics Med\u2010X Center for Materials West China Hospital Sichuan University Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Geng","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sutong","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Frontiers Science Center for Disease\u2010related Molecular Network National Clinical Research Center for Geriatrics Med\u2010X Center for Materials West China Hospital Sichuan University Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Frontiers Science Center for Disease\u2010related Molecular Network National Clinical Research Center for Geriatrics Med\u2010X Center for Materials West China Hospital Sichuan University Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Adeli","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry Lorestan University Khorramabad 6815144316 Iran"},{"name":"Institute of Chemistry and Biochemistry Freie Universitat Berlin Takustr. 3 14195 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering The Macau University of Science and Technology Taipa Macau 999078 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Frontiers Science Center for Disease\u2010related Molecular Network National Clinical Research Center for Geriatrics Med\u2010X Center for Materials West China Hospital Sichuan University Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6872-2240","authenticated-orcid":false,"given":"Chong","family":"Cheng","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 China"},{"name":"Department of Endodontics Department of Orthodontics State Key Laboratory of Oral Diseases &amp; 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