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To address these clinical challenges, a biomimetic nanomotor, Pt@LF is designed, to facilitate deep delivery of neuroprotective agents and inhibit ferroptosis in ischemic stroke. Pt@LF traverses the blood\u2010brain barrier (BBB) and penetrates into deep cerebral ischemic\u2010hypoxic areas due to the active targeting capacity of apo\u2010lactoferrin (Apo\u2010LF) and the self\u2010propelling motion properties of nanomotors. Subsequently, Pt@LF loosens thrombus and alleviates the \u201cno reflow\u201d phenomenon via mechanical thrombolysis. Thanks to the various enzyme\u2010like abilities and multi\u2010target ferroptosis inhibition capability, Pt@LF ameliorates the inflammatory microenvironment and rescues dying neurons. In conclusion, Pt@LF demonstrates efficiently deep penetration and neuroprotective effects in vitro and vivo. 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