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PANoptosis, a form of inflammatory programmed cell death, presents a dependable strategy for combating cancer by engaging multiple cell death pathways (apoptosis, pyroptosis, and necroptosis). In this study, an ultrasmall Bi\n                    <jats:sub>2<\/jats:sub>\n                    Sn\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>7<\/jats:sub>\n                    nanozyme with ultrasound\u2010magnified multienzyme\u2010mimicking properties is designed and engineered as a PANoptosis inducer through destroying the mitochondrial function of tumor cells and enhancing the intracellular accumulation of toxic reactive oxygen species, finally triggering the activation of PANoptosis process. The role of PANoptosis inducer has been verified by the expression of related proteins, including cleaved Caspase 3, NLRP3, N\u2010GSDMD, cleaved Caspase 1, p\u2010MLKL, and RIPK3. The inclusion of external ultrasonic irradiation significantly augments the enzyodynamic therapeutic efficiency. In vitro and in vivo antineoplastic efficacy, along with inhibition of lung metastasis, validate the benefits of the Bi\n                    <jats:sub>2<\/jats:sub>\n                    Sn\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>7<\/jats:sub>\n                    \u2010mediated PANoptosis pathway. This study not only elucidates the intricate mechanisms underlying Bi\n                    <jats:sub>2<\/jats:sub>\n                    Sn\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>7<\/jats:sub>\n                    as a PANoptosis inducer, but also offers a novel perspective for the treatment of hepatocellular carcinoma.\n                  <\/jats:p>","DOI":"10.1002\/adma.202409618","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T08:27:37Z","timestamp":1725352057000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Ultrasmall Enzyodynamic PANoptosis Nano\u2010Inducers for Ultrasound\u2010Amplified Hepatocellular Carcinoma Therapy and Lung Metastasis Inhibition"],"prefix":"10.1002","volume":"36","author":[{"given":"Wuyang","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Ultrasound Affiliated Hospital of Southwest Jiaotong University The Third People's Hospital of Chengdu  Chengdu Sichuan 610031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Affiliated Hospital of Southwest Jiaotong University The Third People's Hospital of Chengdu  Chengdu Sichuan 610031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunrong","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Affiliated Hospital of Southwest Jiaotong University The Third People's Hospital of Chengdu  Chengdu Sichuan 610031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruxi","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Affiliated Hospital of Southwest Jiaotong University The Third People's Hospital of Chengdu  Chengdu Sichuan 610031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoxi","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Affiliated Hospital of Southwest Jiaotong University The Third People's Hospital of Chengdu  Chengdu Sichuan 610031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound Shanghai Tenth People's Hospital Ultrasound Research and Education Institute Shanghai Engineering Research Center of Ultrasound Diagnosis and Treatment Tongji University Cancer Center School of Medicine, Tongji University  Shanghai 200072 P. 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