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However, certain diseases with dual resistance barriers to the attacks by both ROS and immune cells, such as bacterial biofilm infections of medical implants, are difficult to eradicate by a single exogenous oxidative stimulus due to the diversity and complexity of the redox species involved. Here, this work demonstrates that metal\u2010organic framework (MOF) nanoparticles capable of disrupting the bacterial ROS\u2010defense system can dismantle bacterial redox resistance and induce potent antimicrobial immune responses in a mouse model of surgical implant infection by simultaneously modulating redox homeostasis and initiating neutrophil N1 polarization in the infection microenvironment. Mechanistically, the piezoelectrically enhanced MOF triggers ROS production by tilting the band structure and acts synergistically with the aurintricarboxylic acid loaded within the MOF, which inhibits the activity of the cystathionine \u03b3\u2010cleaving enzyme. This leads to biofilm structure disruption and antigen exposure through homeostatic imbalance and synergistic activation of neutrophil N1 polarization signals. Thus, this study provides an alternative but promising strategy for the treatment of antibiotic\u2010resistant biofilm infections.<\/jats:p>","DOI":"10.1002\/adma.202409633","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T02:21:12Z","timestamp":1727749272000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Piezoelectric\u2010Enhanced Nanocatalysts Trigger Neutrophil N1 Polarization against Bacterial Biofilm by Disrupting Redox Homeostasis"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6106-2721","authenticated-orcid":false,"given":"Min","family":"Ge","sequence":"first","affiliation":[{"name":"Department of Electrical and Electronic Engineering The University of Hong Kong  Pokfulam Road Hong Kong 999077 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