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Multifunctional nanozymes, leveraging their physiochemical properties and enzymatic activities, offer promising antibacterial and anti\u2010inflammatory strategies for managing periodontitis. In particular, Prussian blue nanozymes (PBzymes) exhibit exceptional ROS control due to their robust catalytic activity, diverse antioxidant functions, and high biocompatibility. However, the practical application of traditional high\u2010temperature synthesis methods is limited. This study introduces a class of metal\u2010engineered PBzymes synthesized at room temperature, identified for their potent antioxidative activity and excellent photothermal performance at mild temperatures. Nitric oxide (NO) gas therapy offers promising strategies for targeting deep infections in periodontal tissues. Thus, sodium nitroprusside is introduced into PBzyme to create SPBzyme via an in situ loading method. NO release by SPBzyme enhances antibacterial effects and overcomes resistance linked to bacterial biofilms, resulting in mild\u2010photothermal antibacterial properties and synergistic antioxidant effects. In vitro antibacterial assays demonstrate the superior efficacy of SPBzyme under mild temperature conditions and near\u2010infrared light exposure. Furthermore, SPBzyme effectively reduces inflammation and has positive therapeutic effects in periodontal animal models. Overall, mild\u2010temperature photothermal NO release nanozyme therapy represents a novel approach for treating periodontitis.<\/jats:p>","DOI":"10.1002\/adma.202409840","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T02:21:36Z","timestamp":1734488496000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["Engineering Mild\u2010Photothermal Responsive and NO Donor Prussian Blue Nanozymes Using Mild Synthesis for Inflammation Regulation and Bacterial Eradication in Periodontal Disease"],"prefix":"10.1002","volume":"37","author":[{"given":"Zheng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Prosthodontics, National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices &amp; Beijing Key Laboratory of Digital Stomatology &amp; NHC Key Laboratory of Digital Stomatology Peking University School and Hospital of Stomatology  22 Zhongguancun South Avenue Beijing Haidian District 100081 P. 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