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Cyclic guanosine monophosphate\u2010adenosine monophosphate synthase (cGAS)\u2010stimulator of interferon gene (STING) pathway activation facilitates tumor\u2010associated macrophage (TAM) polarization toward M1 phenotype, and Mn\n                    <jats:sup>2+<\/jats:sup>\n                    are effective agents for this pathway activation. However, the high in vivo degradation rate and toxicity of Mn\n                    <jats:sup>2+<\/jats:sup>\n                    hamper clinical application of immunotherapy. Here, this work has newly synthesized and screened manganese porphyrins for Mn\n                    <jats:sup>2+<\/jats:sup>\n                    transport, referred to as photo\u2010STING agonists (PSAs), and further encapsulate them into core\u2010shell nanoparticles named Rm@PP\u2010GA with dual specificity for tumor tissue and TAMs. Not only do PSAs achieve higher Mn\n                    <jats:sup>2+<\/jats:sup>\n                    delivery efficiency compared to Mn\n                    <jats:sup>2+<\/jats:sup>\n                    , but they also generate reactive oxygen species under light exposure, promoting mitochondrial DNA release for cGAS\u2010STING pathway activation. In Rm@PP\u2010GA, globin and red blood cell membranes (Rm) are used for erythrocyte efferocytosis\u2010mimicking delivery. Rm can effectively prolong the in vivo circulation period while globin enables PSAs to be taken up by TAMs via CD163 receptors. After Rm rupture mediated by perfluorohexane in nanoparticles under ultrasonication, drugs are specifically released for TAM repolarization. Further, dendritic cells mature, as well as T lymphocyte infiltrate, both of which favor tumor eradication. Therefore, cancer immunotherapy is optimized by novel PSAs delivered by erythrocyte efferocytosis\u2010mimicking delivery pattern.\n                  <\/jats:p>","DOI":"10.1002\/adma.202410937","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T02:59:44Z","timestamp":1728442784000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Novel Photo\u2010STING Agonists Delivered by Erythrocyte Efferocytosis\u2010Mimicking Pattern to Repolarize Tumor\u2010Associated Macrophages for Boosting Anticancer Immunotherapy"],"prefix":"10.1002","volume":"36","author":[{"given":"Zhiyan","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology Division of Gastric Surgery, Department of General Surgery Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical School  Nanjing 210008 China"},{"name":"Jiangsu Key Laboratory of 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