{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T03:19:50Z","timestamp":1792207190987,"version":"4.4.0"},"reference-count":71,"publisher":"Wiley","issue":"48","license":[{"start":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T00:00:00Z","timestamp":1728691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T00:00:00Z","timestamp":1728691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFE0200089"],"award-info":[{"award-number":["2024YFE0200089"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1100603"],"award-info":[{"award-number":["2021YFA1100603"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2019M663525"],"award-info":[{"award-number":["2019M663525"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Traumatic spinal cord injury (SCI) represents a complex neuropathological challenge that significantly impacts the well\u2010being of affected individuals. The quest for efficacious antioxidant and anti\u2010inflammatory therapies is both a compelling necessity and a formidable challenge. Here, in this work, the innovative synthesis of electron\u2010rich Ru clusters on non\u2010stoichiometric copper hydroxide that contain oxygen vacancy defects (Ru\/def\u2010Cu(OH)\n                    <jats:sub>2<\/jats:sub>\n                    ), which can function as a biocatalytic reactive oxygen species (ROS) scavenger for efficiently suppressing the inflammatory cascade reactions and modulating the endogenous microenvironments in SCI, is introduced. The studies reveal that the unique oxygen vacancies promote electron redistribution and amplify electron accumulation at Ru clusters, thus enhancing the catalytic activity of Ru\/def\u2010Cu(OH)\n                    <jats:sub>2<\/jats:sub>\n                    in multielectron reactions involving oxygen\u2010containing intermediates. These advancements endow the Ru\/def\u2010Cu(OH)\n                    <jats:sub>2<\/jats:sub>\n                    with the capacity to mitigate ROS\u2010mediated neuronal death and to foster a reparative microenvironment by dampening inflammatory macrophage responses, meanwhile concurrently stimulating the activity of neural stem cells, anti\u2010inflammatory macrophages, and oligodendrocytes. Consequently, this results in a robust reparative effect on traumatic SCI. It is posited that the synthesized Ru\/def\u2010Cu(OH)\n                    <jats:sub>2<\/jats:sub>\n                    exhibits unprecedented biocatalytic properties, offering a promising strategy to develop ROS\u2010scavenging and anti\u2010inflammatory materials for the management of traumatic SCI and a spectrum of other diseases associated with oxidative stress.\n                  <\/jats:p>","DOI":"10.1002\/adma.202411618","type":"journal-article","created":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T05:44:43Z","timestamp":1728711883000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Constructing Electron\u2010Rich Ru Clusters on Non\u2010Stoichiometric Copper Hydroxide for Superior Biocatalytic ROS Scavenging to Treat Inflammatory Spinal Cord Injury"],"prefix":"10.1002","volume":"36","author":[{"given":"Jinglun","family":"Liu","sequence":"first","affiliation":[{"name":"Engineering Research Center 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