{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:29:19Z","timestamp":1792009759886,"version":"4.4.0"},"reference-count":74,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52322309"],"award-info":[{"award-number":["52322309"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52173139"],"award-info":[{"award-number":["52173139"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52173079"],"award-info":[{"award-number":["52173079"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["xtr052023001"],"award-info":[{"award-number":["xtr052023001"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["xzy012023037"],"award-info":[{"award-number":["xzy012023037"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hydrogels with mechanical performances similar to load\u2010bearing tissues are in demand for in vivo applications. In this work, inspired by the self\u2010assembly behavior of amphiphilic polymers, polyurethane\u2010based tough hydrogels with a multiple hydrogen\u2010bond interlocked bicontinuous phase structure through in situ water\u2010induced microphase separation strategy are developed, in which poly(ethylene glycol)\u2010based polyurethane (PEG\u2010PU, hydrophilic) and poly(\u03b5\u2010caprolactone)\u2010based polyurethane (PCL\u2010PU, hydrophobic) are blended to form dry films followed by water swelling. A multiple hydrogen bonding factor, imidazolidinyl urea, is introduced into the synthesis of the two polyurethanes, and the formation of multiple hydrogen bonds between PEG\u2010PU and PCL\u2010PU can promote homogeneous microphase separation for the construction of bicontinuous phase structures in the hydrogel network, by which the hydrogel features break strength of 12.9 MPa, fracture energy of 2435 J m\n                    <jats:sup>\u22122<\/jats:sup>\n                    , and toughness of 48.2 MJ m\n                    <jats:sup>\u22123<\/jats:sup>\n                    . As a biomedical patch, the outstanding mechanical performances can withstand abdominal pressure to prevent hernia formation in the abdominal wall defect model. Compared to the commercial PP mesh, hydrogel can prevent tissue\/organ adhesion to reduce inflammatory responses and promote angiogenesis, thereby accelerating the repair of abdominal wall defects. This work may provide useful inspiration for researchers to design different gel materials through solvent\u2010induced microphase separation.\n                  <\/jats:p>","DOI":"10.1002\/adma.202412083","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T05:28:48Z","timestamp":1734931728000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":133,"title":["Tough Polyurethane Hydrogels with a Multiple Hydrogen\u2010Bond Interlocked Bicontinuous Phase Structure Prepared by In Situ Water\u2010Induced Microphase Separation"],"prefix":"10.1002","volume":"37","author":[{"given":"Ruyue","family":"Wang","sequence":"first","affiliation":[{"name":"Engineering Research Center of Energy Storage Materials and Devices Ministry of Education School of Chemistry Xi'an Jiaotong University  Xi'an 710049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Xu","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Energy Storage Materials and Devices Ministry of Education School of Chemistry Xi'an Jiaotong University  Xi'an 710049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of Stomatology Xi'an Jiaotong University  Xi'an 710049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Energy Storage Materials and Devices Ministry of Education School of Chemistry Xi'an Jiaotong University  Xi'an 710049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruilin","family":"Xie","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Energy Storage Materials and Devices Ministry of Education School of Chemistry Xi'an Jiaotong University  Xi'an 710049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilong","family":"Cheng","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Energy Storage Materials and Devices Ministry of Education School of Chemistry Xi'an Jiaotong University  Xi'an 710049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4711-8690","authenticated-orcid":false,"given":"Yanfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Energy Storage Materials and Devices Ministry of Education School of Chemistry Xi'an Jiaotong University  Xi'an 710049 China"},{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of Stomatology Xi'an Jiaotong University  Xi'an 710049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,23]]},"reference":[{"key":"e_1_2_8_1_1","first-page":"307","volume":"521","author":"Constantinos N.","year":"2004","journal-title":"J. Physiol."},{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200304907"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.1c04649"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.9.2879"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.0c00238"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/12_072"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202401678"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2016.71"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11409"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201604327"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b02298"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-47796-2"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1154295"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202209565"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201704195"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2019.122832"},{"key":"e_1_2_8_12_3","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b21659"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202100047"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40820-018-0195-3"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b05318"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202209497"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09351-2"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.compositesa.2011.06.003"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03212-z"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202007829"},{"key":"e_1_2_8_16_3","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202305400"},{"key":"e_1_2_8_16_4","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202307290"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1903019116"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201900702"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202301532"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202101500"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202108745"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43334-8"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.04.007"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202212130"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-022-01195-4"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c18242"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.8b05262"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1039\/C9MH01844A"},{"key":"e_1_2_8_24_1","first-page":"4251","volume":"1","author":"Fan C. J.","year":"2013","journal-title":"J. Phys. Chem. B"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2017.06.003"},{"key":"e_1_2_8_24_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.01.297"},{"key":"e_1_2_8_24_4","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b01989"},{"key":"e_1_2_8_24_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2022.120229"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.8b01208"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.117978"},{"key":"e_1_2_8_25_3","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c00819"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202206819"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.138212"},{"key":"e_1_2_8_26_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2018.05.023"},{"key":"e_1_2_8_26_4","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c04781"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116797"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2022.119268"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202210395"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202203049"},{"key":"e_1_2_8_28_3","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202207348"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8442(89)90024-4"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202210092"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.1c01595"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2019.12.016"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tca.2011.07.003"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma034695a"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.2c00669"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/masy.200750446"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.09.019"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201001215"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b07105"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202301551"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202005314"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-434621"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c07753"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.202300737"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adl2737"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2024.115300"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202412083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T12:27:46Z","timestamp":1759753666000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202412083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,23]]},"references-count":74,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/adma.202412083"],"URL":"https:\/\/doi.org\/10.1002\/adma.202412083","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,23]]},"assertion":[{"value":"2024-08-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2412083"}}