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Additionally, diabetes mellitus exacerbates periodontitis, resulting in expedited resorption of periodontal bone. However, methods such as mechanical debridement, anti\u2010inflammatory medications, and surgical approaches often fail to eradicate local infections and inflammation, complicating the reconstruction of periodontal tissue structures. Consequently, there is an urgent need to devise a novel strategy for managing diabetic periodontal conditions. Here, a multifunctional controlled\u2010release drug delivery system (GOE1) is developed by encapsulating self\u2010assembled nanoparticles (consisting of chlorhexidine acetate and epigallocatechin\u20103\u2010gallate) into a hydrogel matrix composed of gelatin methacryloyl and oxidized hyaluronic acid. In vitro experiments demonstrate that the GOE1 hydrogel possesses good antimicrobial, antioxidant and anti\u2010inflammatory properties, and transgenic sequence genomics further illustrates that IL\u201017\u2010producing RAW 264.7 macrophages are critical for mediating M1\/M2 macrophage transition and provide favorable immune microenvironment. In addition, in vivo experiments reveal that GOE1 significantly ameliorates periodontal tissue inflammation and reduces the loss of alveolar bone by reducing inflammatory infiltration and collagen destruction. Overall, the GOE1 hydrogel offers a promising therapeutic option for managing diabetic periodontitis.<\/jats:p>","DOI":"10.1002\/adma.202412240","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T01:57:03Z","timestamp":1732845423000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":165,"title":["An Immunomodulatory Hydrogel Featuring Antibacterial and Reactive Oxygen Species Scavenging Properties for Treating Periodontitis in Diabetes"],"prefix":"10.1002","volume":"37","author":[{"given":"Xinxin","family":"Ge","sequence":"first","affiliation":[{"name":"School &amp; Hospital of Stomatology Wenzhou Medical University  Wenzhou Zhejiang 325027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Hu","sequence":"additional","affiliation":[{"name":"School &amp; Hospital of Stomatology Wenzhou Medical University  Wenzhou Zhejiang 325027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2480-7242","authenticated-orcid":false,"given":"Xiaoliang","family":"Qi","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Ophthalmology and Optometry Eye Hospital Wenzhou Medical University  Wenzhou Zhejiang 325027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizuo","family":"Shi","sequence":"additional","affiliation":[{"name":"School &amp; 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