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Despite the rapid growth in the generation of organoids, in vitro assay tools are still limited to 2D forms. Thus, a comprehensive and continuous functional evaluation of the electrogenic organoids remains a challenge. Here, a highly stretchable 3D multielectrode array (sMEA) with protruding microelectrodes is presented for functional evaluation of electrogenic organoids. The optimized serpentine structures with bridge structures cover the surface of the organoids conformally even in immersion. The protruding microelectrodes form a stable contact with the organoids and allow electrophysiological recordings with high signal\u2010to\u2010noise ratio (SNR). sMEAs are fabricated in wafer\u2010scale for repeatable, scalable, and mass production and packed into an easy\u2010to\u2010use, user\u2010friendly, and robust microwell for fast dissemination of technology. The versatility of sMEA is validated by measuring electrophysiological signals from cardiac spheroids and midbrain organoids with a wide range of sizes from 500 to 1500\u00a0\u00b5m. Also, electrophysiological signals recorded with high SNR enable functional evaluation of the effects of drugs. The proposed sMEA with high SNR and user\u2010friendly interface could be the key player in high\u2010throughput drug screening, 3D spatiotemporal mapping of electrogenic organoids, and standardization of protocols for quality assessment.<\/jats:p>","DOI":"10.1002\/adma.202412953","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T02:46:17Z","timestamp":1734317177000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Highly Stretchable 3D Microelectrode Array for Noninvasive Functional Evaluation of Cardiac Spheroids and Midbrain Organoids"],"prefix":"10.1002","volume":"37","author":[{"given":"Kiup","family":"Kim","sequence":"first","affiliation":[{"name":"School of Electrical Engineering Korea Advanced Institute of Science and Technology (KAIST)  Daejeon 34141 Republic of 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