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The high dissipation characteristics in the electromechanical conversion of piezoelectric biomaterials pose a challenge. Therefore, supramolecular engineering and microfluidic technology is utilized to introduce slide\u2010ring polyrotaxane and conductive polypyrrole to construct stress\u2010electric coupling hydrogel microspheres. The molecular slippage mechanism of slide\u2010ring structure stores and releases mechanical energy, reducing mechanical loss, the piezoelectric barium titanate enables stress\u2010electricity conversion, and conjugated \u03c0\u2010electron movement in conductive network improves the internal electron transfer efficiency of microspheres, thereby reducing the loss in stress\u2010electricity conversion for the first time. Compared to traditional piezoelectric hydrogel microspheres, the stress\u2010electric coupling efficiency of low\u2010dissipation microspheres increased by 2.3 times, and the energy dissipation decreased to 43%. At cellular level, electrical signals generated by the microspheres triggered Ca\n                    <jats:sub>2+<\/jats:sub>\n                    influx into stem cells and upregulated the cAMP signaling pathways, promoting chondrogenic differentiation. Enhanced electrical signals induced macrophage polarization to the M2 phenotype, reshaping inflammation and promoting tissue repair. In vivo, the low\u2010dissipation microspheres restored low\u2010loss transduction between tissues, alleviated cartilage damage, improved behavioral outcomes, and promoted the treatment of osteoarthritis in rats. Therefore, this study proposes a new strategy for restoring low\u2010loss transduction between tissues, particularly in mechanically sensitive tissues.\n                  <\/jats:p>","DOI":"10.1002\/adma.202413156","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T03:55:24Z","timestamp":1735790124000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Slide\u2010Ring Structured Stress\u2010Electric Coupling Hydrogel Microspheres for Low\u2010Loss Transduction Between Tissues"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6296-402X","authenticated-orcid":false,"given":"Fan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  197 Ruijin 2nd Road Shanghai 200025 P. 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