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Herein,\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetyl\u2010\n                    <jats:sc>l<\/jats:sc>\n                    \u2010cysteine\u2013derived carbonized polymer dots (NAC CPDs) are embedded into manganese porphyrin\u2013doped metal\u2013organic frameworks and encapsulated using a polydopamine (PDA) coating and gelatin methacryloyl (GelMA) hydrogel to afford functionalized nanozyme microcapsules. Owing to their injectability and adhesion properties, these microcapsules exhibit the advantages of prolonged retention in the middle ear and sustained release in the inner ear. The synergy between the manganese porphyrin and polymer dots results in excellent antioxidant properties. The developed nanozymes activate the PI3K\u2010AKT pathway, reprogramming the energy supply mechanism, and inhibiting the oligomerization of BAX in mitochondria to prevent the leakage of mitochondrial DNA and cytochrome c. Therapeutic efficacy and related mechanisms are validated in vivo. Thus, this study on mitochondrial homeostasis remodeling by nanozyme microcapsules opens a new chapter in the treatment of hearing loss.\n                  <\/jats:p>","DOI":"10.1002\/adma.202413371","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T01:27:33Z","timestamp":1733966853000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Functionalized Nanozyme Microcapsules Targeting Deafness Prevention via Mitochondrial Homeostasis Remodeling"],"prefix":"10.1002","volume":"37","author":[{"given":"Shengjie","family":"Ge","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery The Affiliated Hospital of Yangzhou University Yangzhou University  Yangzhou 225001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aidong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery The Affiliated Hospital of Yangzhou University Yangzhou University  Yangzhou 225001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery The Affiliated Hospital of Yangzhou University Yangzhou University  Yangzhou 225001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Qingzhou People's Hospital  Qingzhou 262500 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Chemo\u2010radiotherapy The Affiliated Hospital of Yangzhou University Yangzhou University  Yangzhou 225001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotao","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery The Affiliated Hospital of Yangzhou University Yangzhou University  Yangzhou 225001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery The Affiliated Hospital of Yangzhou University Yangzhou University  Yangzhou 225001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery The Affiliated Hospital of Yangzhou University Yangzhou University  Yangzhou 225001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery The Affiliated Hospital of Yangzhou University Yangzhou University  Yangzhou 225001 China"},{"name":"Departments of Otolaryngology\u2010Head and Neck Surgery The First Affiliated Hospital of University of Science and Technique of China  Hefei 230001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4468-2878","authenticated-orcid":false,"given":"Guang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery The Affiliated Hospital of Yangzhou University Yangzhou University  Yangzhou 225001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12062347"},{"key":"e_1_2_8_2_1","volume":"30","author":"Li S.","year":"2021","journal-title":"Front. 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