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The disease is challenging to manage due to its exposure to a wet and dynamic oral environment, where conventional hydrogels often suffer from weak adhesion, short residence time, and vulnerability to bacterial invasion. In this study, an innovative hydrogel system based on in situ light curing is proposed. The hydrogel precursor, comprising sodium alginate and a calcium ion network, is designed and adhere to the irregular and smooth surfaces of periodontal tissue before curing. Upon light irradiation, a second network polymerizes rapidly, establishing multiple interactions with the tissue, which enhances adhesion strength. Benefited from this engineering strategy, the hydrogel\u00a0exhibits a low swelling rate, effectively mitigating adhesion loss in the moist oral environment. Additionally, the hydrogel demonstrates excellent long\u2010lasting wet adhesion, maintaining its presence in periodontal tissue over 120 hours. It also serves as an effective physical barrier against bacterial invasion, achieving a blocking efficiency of 99.9%. This novel design concept offers a promising approach for developing advanced medical dressings for periodontitis, providing sustained therapeutic benefits.<\/jats:p>","DOI":"10.1002\/adma.202413373","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T02:00:54Z","timestamp":1732154454000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Adaptable Hydrogel with Strong Adhesion of Wet Tissue for Long\u2010Term Protection of Periodontitis Wound"],"prefix":"10.1002","volume":"37","author":[{"given":"Honggui","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Chemical Resource Engineering Key Lab of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology Ministry of Education) Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 100029 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