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To address this demand, it is proposed utilizing a natural biomaterial, silk sericin (SS), which exhibits valuable biological activities and contains abundant asymmetric amino acids with adjustable structures, to create an implantable self\u2010powered system based on the piezoelectric principle. The functionalized SS\u2010based (F\u2010SS\u2010based) piezoelectric film demonstrates a high longitudinal piezoelectric tensor (\n                    <jats:italic>d<\/jats:italic>\n                    <jats:sub>33<\/jats:sub>\n                    ) of 12\u00a0pC\u00a0N\n                    <jats:sup>\u22121<\/jats:sup>\n                    . An energy\u2010generating device (EG device) utilizing this piezoelectric film can generate electric energy under mechanical force both in vitro and in vivo. By manually tapping the EG\u2010device for a few minutes, the accumulated electricity in a commercial capacitor (1.1\u00a0\u00b5F) could illuminate LEDs or operate a timer. Furthermore, the instantaneous energy power density (218.5\u00a0\u00b5W\u00a0m\n                    <jats:sup>\u22122<\/jats:sup>\n                    ) achieved by manual pressing the EG device is sufficient to deliver effective pacing to restart a non\u2010beating heart or normalize an atrioventricular block in a preclinical model. Owing to its high biocompatibility and biodegradability in physiological environments, the F\u2010SS\u2010based EG device holds significant promise for the advancement of self\u2010powered power systems for next\u2010generation CIEDs and other implantable and degradable electronic devices.\n                  <\/jats:p>","DOI":"10.1002\/adma.202413610","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T01:35:59Z","timestamp":1741743359000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["An Implantable and Degradable Silk Sericin Protein Film Energy Harvester for Next\u2010Generation Cardiovascular Electronic Devices"],"prefix":"10.1002","volume":"37","author":[{"given":"Qiying","family":"Lv","sequence":"first","affiliation":[{"name":"Hubei Key Laboratory of Regenerative Medicine and Multi\u2010disciplinary Translational Research; Hubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment; Research Center for Tissue Engineering and Regenerative Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Song","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Regenerative Medicine and Multi\u2010disciplinary Translational Research; Hubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment; Research Center for Tissue Engineering and Regenerative Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaodeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Xiao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of Education Hubei Key Laboratory of Material Chemistry and Service Failure; School of Chemistry and Chemical Engineering Huazhong University of Science and Technology  Wuhan 430074 P. 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