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Drug\u2010delivery nerve conduits play a role in repairing the regenerative microenvironment. However, traditional drugs often fail to cross the blood\u2010nerve barrier and lack multifunctionality, limiting the effectiveness of conduit therapy. Therefore, it is necessary to construct a multifunctional conduit that regulate the regeneration microenvironment timely and effectively. Herein, a photo\u2010responsive hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) composite nerve conduit, artificially controlled H\n                    <jats:sub>2<\/jats:sub>\n                    S release, is developed. A new structure of zinc\u2010citric acid organic metal framework (Zn\u2010CA MOFs) is utilized to improve its drug loading rate, achieving the joint regulation of the nerve regeneration microenvironment by H\n                    <jats:sub>2<\/jats:sub>\n                    S and Zn\n                    <jats:sup>2+<\/jats:sup>\n                    . In addition, RGD modification of polyester amide (P(CL\u2010MMD\u2010MAC)\u2010RGD)) combined with aligned structure is used to improve the performance of the conduit. Relevant results demonstrate that H\n                    <jats:sub>2<\/jats:sub>\n                    S and Zn\n                    <jats:sup>2+<\/jats:sup>\n                    can regulate inflammatory response and oxidative stress and promote mitochondrial function recovery and angiogenesis. Furthermore, the aligned structure can promote cell adhesion and guide cell directed migration. Overall, this study provides a method of combining gas neurotransmitters with ions to improve the nerve regeneration microenvironment, accelerate nerve regeneration, and restore motor function.\n                  <\/jats:p>","DOI":"10.1002\/adma.202413992","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T16:56:51Z","timestamp":1741712211000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Photo\u2010Responsive H\n                    <sub>2<\/sub>\n                    S Composite System Regulates the Nerve Regeneration Microenvironment Through Multiple Pathways"],"prefix":"10.1002","volume":"37","author":[{"given":"Yuanfang","family":"Huo","sequence":"first","affiliation":[{"name":"State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Biomedical Materials and Engineering Research Center of Hubei Province Wuhan University of Technology  Wuhan 430070 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