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However, the compact cell membranes of pathogenic bacteria, especially drug\u2010resistant bacteria, significantly diminish the efficiency of heat conduction and impede the entrance of reactive oxygen species (ROS) into cells, resulting in unsatisfactory sterilization. Enlightened by the membrane feature of competent bacteria, herein a MXene\/CaO\n                    <jats:sub>2<\/jats:sub>\n                    bio\u2010heterojunction (MC bio\u2010HJ) is elaborated to achieve rapid disinfection and promote infected tissue regeneration through activating competent cell\u2010like antibacterial tactics. The bio\u2010HJ first compels pathogenic bacteria to become a competent cell\u2010like stage through the coordination of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    and membrane phospholipid, and potentiates the membrane permeability. Assisted by near infrared (NIR) irradiation, the heat and ROS generated from PTT and PDT of bio\u2010HJ easily pass through bacterial membrane and drastically perturb bacterial metabolism, leading to rapid disinfection. More importantly, employing two in vivo infected model of mice, it have corroborated that the MC bio\u2010HJs not only effectively accelerate MRSA\u2010infected cutaneous regeneration, but also considerably boost osseointegration in an infected bone defect after coating on orthopedic implants. As envisaged, this work demonstrates a novel therapeutic tactic with robust antibacterial effect to remedy infected tissue regeneration through activating competent cell\u2010like stage.\n                  <\/jats:p>","DOI":"10.1002\/adma.202414111","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:55:48Z","timestamp":1728867348000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":102,"title":["Elaborated Bio\u2010Heterojunction With Robust Sterilization Effect for Infected Tissue Regeneration via Activating Competent Cell\u2010Like Antibacterial Tactic"],"prefix":"10.1002","volume":"36","author":[{"given":"Yixuan","family":"Huang","sequence":"first","affiliation":[{"name":"School of Chemical Engineering West China Hospital of Stomatology Sichuan University  Chengdu 610065 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