{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:49:18Z","timestamp":1791467358524,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T00:00:00Z","timestamp":1737244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1305100"],"award-info":[{"award-number":["2022YFA1305100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFA1509203"],"award-info":[{"award-number":["2024YFA1509203"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22175168"],"award-info":[{"award-number":["22175168"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22475207"],"award-info":[{"award-number":["22475207"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Currently, there is no conclusive evidence indicating that in situ self\u2010assembled Gd nanostructures of varying sizes demonstrate distinct T\n                    <jats:sub>1<\/jats:sub>\n                    and T\n                    <jats:sub>2<\/jats:sub>\n                    signal enhancement capabilities. Furthermore, it remains uncertain whether size adjustment can effectively achieve enhanced T\n                    <jats:sub>1<\/jats:sub>\n                    \u2010T\n                    <jats:sub>2<\/jats:sub>\n                    dual\u2010modal MRI. To address these uncertainties, a two\u2010step in situ self\u2010assembly strategy is developed. This approach began with a small\u2010sized nanoprobe, Gd\u2010TCO\u2010P, with a hydrodynamic diameter (dH) of 16 \u00b1\u00a03\u00a0nm. This nanoprobe underwent alkaline phosphatase (ALP) cleavage and self\u2010assembled intracellularly into short nanofibers termed Gd\u2010NFs (dH: 200 \u00b1\u00a051\u00a0nm). The subsequent introduction of tetrazine\u2010tetrazine crosslinked these Gd\u2010NFs, leading to the formation of larger two\u2010stage dendritic nanofibers known as Gd\u2010TS\u2010NFs (dH: 4371 \u00b1\u00a0236\u00a0nm). This process achieves size\u2010dependent enhancement of both T\n                    <jats:sub>1<\/jats:sub>\n                    and T\n                    <jats:sub>2<\/jats:sub>\n                    signals, which is validated through both in vitro and in vivo experiments, enabling precise long\u2010term imaging of ALP\u2010overexpressing tumors. This study not only provides valuable insights into the relationship between the size of in situ formed Gd nanostructures and T\n                    <jats:sub>1<\/jats:sub>\n                    \/T\n                    <jats:sub>2<\/jats:sub>\n                    MRI contrast enhancement, but also suggests a promising strategy for clinical applications of T\n                    <jats:sub>1<\/jats:sub>\n                    \u2010T\n                    <jats:sub>2<\/jats:sub>\n                    dual\u2010modal MRI.\n                  <\/jats:p>","DOI":"10.1002\/adma.202414201","type":"journal-article","created":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T22:18:27Z","timestamp":1737325107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Size\u2010Dependent Cascade Enhancement of T\n                    <sub>1<\/sub>\n                    \u2010T\n                    <sub>2<\/sub>\n                    Dual\u2010Modal MRI in Tumors"],"prefix":"10.1002","volume":"37","author":[{"given":"Yanyun","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Precision and Intelligent Chemistry University of Science and Technology of China  Hefei Anhui 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine The First Affiliated Hospital of Anhui Medical University  Hefei Anhui 230022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Tong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Precision and Intelligent Chemistry University of Science and Technology of China  Hefei Anhui 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajing","family":"Dong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Precision and Intelligent Chemistry University of Science and Technology of China  Hefei Anhui 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaoxin","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Precision and Intelligent Chemistry University of Science and Technology of China  Hefei Anhui 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangtao","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zian","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Precision and Intelligent Chemistry University of Science and Technology of China  Hefei Anhui 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Engineering Hefei Normal University  Hefei Anhui 230061 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhui","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine The First Affiliated Hospital of Anhui Medical University  Hefei Anhui 230022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2653-8963","authenticated-orcid":false,"given":"Yue","family":"Yuan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Precision and Intelligent Chemistry University of Science and Technology of China  Hefei Anhui 230026 China"},{"name":"The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui 230026 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