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To overcome these limitations, a self\u2010sustained organelle\u2010mimicking nanoreactor is developed here with programmable DNA switches that enables bio\u2010chem\u2010photocatalytic cascade\u2010driven starvation\u2010photodynamic synergistic therapy against tumor metastasis. Emulating the compartmentalization and positional assembly strategies found in living cells, this nano\u2010organelle reactor allows quantitative co\u2010compartmentalization of multiple functional modules for the designed self\u2010illuminating chemiexcited PDT system. Within the space\u2010confined nanoreactor, biofuel glucose is converted to hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) which enhances luminol\u2010based chemiluminescence (CL), consequently driving the generation of photochemical singlet oxygen (\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) via chemiluminescence resonance energy transfer. Meanwhile, hemoglobin functions as a synchronized oxygen supplier for both glucose oxidation and PDT, while also exhibiting peroxidase\u2010like activity to produce hydroxyl radicals (\u00b7OH). Crucially, the nanoreactor keeps switching off in normal tissues, with on\u2010demand activation in tumors through toehold\u2010mediated strand displacement. These findings demonstrate that this nanoreactor, which is self\u2010sufficient in light and oxygen and precise in striking tumors, presents a promising paradigm for managing highly metastatic cancers.\n                  <\/jats:p>","DOI":"10.1002\/adma.202415030","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T02:11:47Z","timestamp":1736561507000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Self\u2010Sustained Biophotocatalytic Nano\u2010Organelle Reactors with Programmable DNA Switches for Combating Tumor Metastasis"],"prefix":"10.1002","volume":"37","author":[{"given":"Wenshuai","family":"Han","sequence":"first","affiliation":[{"name":"Key Laboratory of Marine Drugs Chinese Ministry of Education School of Medicine and Pharmacy Ocean University of China  Qingdao 266003 P. R. 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