{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T15:43:34Z","timestamp":1793720614074,"version":"4.6.1"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T00:00:00Z","timestamp":1736035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A20308"],"award-info":[{"award-number":["U21A20308"]}],"id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22077088"],"award-info":[{"award-number":["22077088"]}],"id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Breast cancer (BC) is the second most common cause of cancer induced death worldwide. Current statistics has disclosed that the diabetic BC patients have significantly worse survival rate compared with nondiabetic BC patients. However, the specific mechanism is still being explored. Herein, a novel NIR\u2010II nanosensor DNPS\u00a0for nitric oxide (NO) with fluorescence\/photoacoustic (FL\/PA)\u00a0imaging capability is developed to explore the mechanism by which diabetes promoting breast cancer progression. In diabetic BC model, DNPS exhibits great advantages of low intrinsic background, high sensitivity, and deep tissue penetration and successfully confirmed the expression level of NO is higher than BC model, indicating that diabetes causes elevated nitric oxide levels in the tumor microenvironment. RNA\u2010seq analysis results show\u00a0that hyperglycemia caused by diabetes leads to weakened immune response and initiates the transcription and translation of the inducible nitric oxide synthase (iNOS) gene to produce NO. Besides, the increased expression of carcinogens related to Nitric oxide synthase 2 (Nos2), such as Spp1, Mmp11, and Kitl, causes breast cancer to develop more rapidly. Here, NIR\u2010II imaging probe is applied first\u00a0to study diabetes\u2010related breast cancer and certain reference value is provided for subsequent research on the mechanism of diabetes promoting the progression of breast cancer.<\/jats:p>","DOI":"10.1002\/adma.202415891","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T01:21:57Z","timestamp":1736126517000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Rational Design of NIR\u2010II Fluorescence\/Photoacoustic Nanosensor Tailored for Mechanisms of Diabetes\u2010Related Breast Cancer"],"prefix":"10.1002","volume":"37","author":[{"given":"Rui\u2010Rui","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Green Chemistry and Technology Ministry of Education College of Chemistry Sichuan University  Chengdu 610064 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Yun","family":"Ran","sequence":"additional","affiliation":[{"name":"Key Laboratory of Green Chemistry and Technology Ministry of Education College of Chemistry Sichuan University  Chengdu 610064 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang\u2010Kang","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bio\u2010Resources and Eco\u2010Environment Ministry of Education College of Life Sciences Sichuan University  Chengdu 610064 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Green Chemistry and Technology Ministry of Education College of Chemistry Sichuan University  Chengdu 610064 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Na","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Green Chemistry and Technology Ministry of Education College of Chemistry Sichuan University  Chengdu 610064 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Fang","family":"Lv","sequence":"additional","affiliation":[{"name":"Key Laboratory of Green Chemistry and Technology Ministry of Education College of Chemistry Sichuan University  Chengdu 610064 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center (HMRRC) Department of Radiology West China Hospital of Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Qi","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Chemistry Xihua University  Chengdu 610039 P. 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