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Current cancer therapies typically lack anxiolytic properties and may even exacerbate anxiety. Here, a gasotransmitter\u2010nanodonors (GND) system is presented that exerts dual anxiolytic and anti\u2010tumor effects via a \u201ctumor\u2010brain axis\u201d strategy. The GND, synthesized by co\u2010embedding Fe\n                    <jats:sup>2<\/jats:sup>\n                    \u207a and S\n                    <jats:sup>2<\/jats:sup>\n                    \u207b ions along with glucose oxidase (GOx) within bovine serum albumin (BSA) nanoparticles (FSG@AB), enables the controlled release of the gasotransmitter hydrogen sulfide (H\u2082S) in the acidic tumor microenvironment. H\u2082S and GOx synergistically deplete tumor energy sources, resulting in robust anti\u2010tumor effects. Meanwhile, H\u2082S generated at the tumor site is transported through the bloodstream to the anterior cingulate cortex (ACC) in the brain, where it modulates neuronal activity. Specifically, in the ACC, H\u2082S upregulates glutamate transporter 1 (GLT\u20101), which reduces extracellular glutamate levels and attenuates the hyperactivity of glutamatergic neurons, thereby alleviating anxiety\u2010like behavior. This study proposes a GND system that targets both oncological and psychiatric dimensions of cancer through the \u201ctumor\u2010brain axis\u201d strategy, resulting in improved therapeutic outcomes.\n                  <\/jats:p>","DOI":"10.1002\/adma.202416481","type":"journal-article","created":{"date-parts":[[2025,3,9]],"date-time":"2025-03-09T10:17:26Z","timestamp":1741515446000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Gasotransmitter\u2010Nanodonor for Spatial Regulation of Anxiety\u2010Like Behavior and Bone Metastasis"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6360-1557","authenticated-orcid":false,"given":"Jiqian","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Anhui Medical University Key Laboratory of Anesthesia and Perioperative Medicine of Anhui Higher Education Institutes Anhui 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