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To address these challenges, a personalized 3D\u2010printed anti\u2010tumor vaccine (3D\u2010Vax\u2010L) is developed that integrates whole tumor antigens from postoperative tissue lysates with the angiogenesis inhibitor, lenvatinib. This vaccine not only possesses inherent adjuvant properties but also mimics the functions of lymph nodes through its porous structure, facilitating the recruitment and maturation of immune cells. In vivo studies in OSCC animal models, including mice and rabbits, demonstrate that 3D\u2010Vax\u2010L effectively recruits and matures immune cells at postoperative sites, inhibits angiogenesis and tumor recurrence, and extends survival time, all while maintaining a stable morphology and an excellent biosafety. Furthermore, 3D\u2010Vax\u2010L supports facial integrity post\u2010surgery, addressing physical challenges by preventing collapse and reducing the risk of aesthetic\u2010related disorders. These findings suggest that 3D\u2010Vax\u2010L is a promising therapeutic technique for preventing post\u2010surgical OSCC relapse, particularly as it offers a new strategy for immune system activation and demonstrates significant potential for clinical translation.<\/jats:p>","DOI":"10.1002\/adma.202417708","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T06:50:42Z","timestamp":1753426242000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Personalized 3D Vaccine Integrates Immunotherapy and Antiangiogenic Therapy to Prevent Oral Squamous Cell Carcinoma Recurrence"],"prefix":"10.1002","volume":"37","author":[{"given":"Jinna","family":"Ren","sequence":"first","affiliation":[{"name":"Department of General Dentistry II Peking University School and Hospital of Stomatology &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; 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