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However, endotoxins released from Gram\u2010negative bacteria cause inflammatory reaction, leading to corneal structural damage and scar formation. Given that polymyxin B (PMB) can bind and neutralize lipopolysaccharide (LPS), this study employs large\u2010pore mesoporous silica nanoparticles (lMSNs) grafted with PMB as carriers for cationic antibacterial carbon quantum dots (CQDs) to prepare CQD@lMSN\u2010PMB, which enables synchronous sterilization and endotoxin neutralization. In the acidic infectious microenvironment, the accelerated release of CQDs eliminates 99.88% bacteria within 2\u00a0h, effectively substituting immune mediated sterilization. Notably, CQD@lMSN\u2010PMB exhibits exceptional LPS neutralization performance (2.22\u00a0\u00b5g LPS\/mg CQD@lMSN\u2010PMB) due to its high specific surface area. In an infectious keratitis model, inflammation subsides significantly within the first day of CQD@lMSN\u2010PMB intervention and is completely resolved by day 3. By day 2, interleukin\u20101\u03b2, interleukin\u20106 and tumor necrosis factor\u2010\u03b1 in CQD@lMSN\u2010PMB group decrease by 86.99%, 91.15%, and 77.56%, respectively, compared to the CQDs\u2010only sterilization group. Ultimately, corneal integrity and transparency are preserved, with suppressed expressions of fibrosis\u2010related factors including matrix metalloproteinase 9, transforming growth factor\u2010\u03b2 and \u03b1\u2010smooth muscle actin. Therefore, this synchronous sterilization and endotoxin neutralization strategy outperforms monotherapy strategies focused solely on sterilization or endotoxin neutralization.<\/jats:p>","DOI":"10.1002\/adma.202419209","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T04:50:22Z","timestamp":1743569422000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Synchronous Sterilization and Immunoreaction Termination for Corneal Transparency Protection in Treating <i>Pseudomonas aeruginosa<\/i> Induced Bacterial Keratitis"],"prefix":"10.1002","volume":"37","author":[{"given":"Siyuan","family":"Qian","sequence":"first","affiliation":[{"name":"National Engineering Research Center of Ophthalmology and Optometry Eye Hospital Wenzhou Medical University  Wenzhou 325000 China"},{"name":"State Key Laboratory of Ophthalmology Optometry and Visual Science Eye Hospital Wenzhou Medical University  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