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Whereas, the realization of miniaturized and portable bio\u2010battery orchestrating off\u2010the\u2010shelf devices remains a significant challenge. Here, this work reports the development of a miniaturized and portable bio\u2010battery using living hydrogels containing conductive biofilms encapsulated in an alginate matrix for nerve stimulation. These hydrogels, which can be 3\u2010D printed into customized geometries, retained biologically active characteristics, including electroactivity that facilitates electron generation and the reduction of graphene oxide. By fabricating the living hydrogel into a standard 2032 battery shell with a diameter of 20\u00a0mm, this work successfully creates a miniaturized and portable bio\u2010battery with self\u2010charging performance. The device demonstrates remarkable electrochemical performance with a coulombic efficiency of 99.5% and maintains high cell viability exceeding 90% after operation. Notably, the electricity generated by the bio\u2010battery can be harnessed for nerve stimulation to enable precise control over bioelectrical stimulation and physiological blood pressure signals. This study paves the way for the development of novel, compact, and portable bio\u2010energy devices with immense potential for future advancements in sustainable energy technologies.<\/jats:p>","DOI":"10.1002\/adma.202419249","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T01:00:35Z","timestamp":1741741235000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["3\u2010D Printable Living Hydrogels as Portable Bio\u2010energy Devices"],"prefix":"10.1002","volume":"37","author":[{"given":"Xinyu","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Quantitative Synthetic Biology Shenzhen Key Laboratory of Materials Synthetic Biology Center for Materials Synthetic Biology Shenzhen Institute of Synthetic Biology Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences  Shenzhen 518055 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