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High glucose concentration in the wound remains a major obstacle, necessitating effective strategies to achieve sustained glucose consumption for synergistic diabetic wound therapy. In this study, an Au\u2010based nanomaterial is developed that can adjust its morphology in different therapeutic processes. The prepared Au nanowire (ANW) can be converted into Au nanospheres (AS) under ultrasonic conditions by adjusting the amount of polyethylene glycol (PEG) on its surface for convenient delivery. Intriguingly, AS is depolymerized into ANW again in the wound area, prolonging the retention time, and ensuring continuous consumption of glucose. After constructing the morphologically switchable Au nanowire, a polyvinyl alcohol (PVA) is applied it to microneedle and co\u2010delivered it with hemoglobin (Hb)\u2010resveratrol (RES) nanoparticles for synergistic diabetic wound therapy. In a streptozotocin (STZ)\u2010induced diabetic mouse model, the microneedle degraded gradually, and the Hb\u2010RES nanoparticles synergistically ameliorated hypoxia, scavenged ROS, and inhibited macrophage differentiation into pro\u2010inflammatory M1 phenotypes. During this process, ANW continuously catalyzed glucose through its inherent glucose oxidase activity. Thus, this study provides novel insights into the long\u2010term management of glucose concentration during synergistic diabetic wound healing.<\/jats:p>","DOI":"10.1002\/adma.202419430","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T08:27:03Z","timestamp":1741681623000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Co\u2010Delivery of Morphologically Switchable Au Nanowire and Hemoglobin\u2010Resveratrol Nanoparticles in the Microneedle for Diabetic Wound Healing Therapy"],"prefix":"10.1002","volume":"37","author":[{"given":"Peng","family":"Ye","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory of Lignocellulosic Chemistry College of Material Science and Technology Beijing Forestry University  Beijing 100083 China"},{"name":"State Key Laboratory of Biopharmaceutical Preparation and Delivery Institute of Process Engineering Chinese Academy of Sciences  Beijing 100190 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biopharmaceutical Preparation and Delivery Institute of Process Engineering Chinese Academy of Sciences  Beijing 100190 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengzhe","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Lignocellulosic Chemistry College of Material Science and Technology Beijing Forestry University  Beijing 100083 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Meng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biopharmaceutical Preparation and Delivery Institute of Process Engineering Chinese Academy of Sciences  Beijing 100190 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Lignocellulosic Chemistry College of Material Science and Technology Beijing Forestry University  Beijing 100083 China"},{"name":"State Key Laboratory of Biopharmaceutical Preparation and Delivery Institute of Process Engineering Chinese Academy of Sciences  Beijing 100190 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biopharmaceutical Preparation and Delivery Institute of Process Engineering Chinese Academy of Sciences  Beijing 100190 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghui","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biopharmaceutical Preparation and Delivery Institute of Process Engineering Chinese Academy of Sciences  Beijing 100190 China"},{"name":"Department of Gastroenterology Tongren Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200336 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianyun","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology The University of Hong Kong\u2010Shenzhen Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Lignocellulosic Chemistry College of Material Science and Technology Beijing Forestry University  Beijing 100083 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luying","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Lignocellulosic Chemistry College of Material Science and Technology Beijing Forestry University  Beijing 100083 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiandu","family":"Lei","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Lignocellulosic Chemistry College of Material Science and Technology Beijing Forestry University  Beijing 100083 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7534-6988","authenticated-orcid":false,"given":"Changlong","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Tai'an 271016 China"},{"name":"Medical Science and Technology Innovation Center Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan 250117 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,11]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2013.11.002"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07039"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-024-00693-y"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abe4839"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.108615"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aba9772"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202108348"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44463-w"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43870-3"},{"key":"e_1_2_9_7_3","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202310033"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201801733"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn4030898"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201604894"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-021-00980-7"},{"key":"e_1_2_9_10_2","volume":"34","author":"Changlong W.","year":"2021","journal-title":"Adv. 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