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This study introduces LipClean, an aerogel\u2010based apheresis device specifically designed to remove harmful plasma lipids. LipClean is constructed using hydrophilic cellulose fibers, which serve as a supramolecular platform for synthesizing hydrophobic conjugated polymers through a Sonogashira\u2010Hagihara reaction. These conjugated polymers are then cross\u2010linked with the cellulose fibers via phosphorylation, generating an aerogel monolith with an interpenetrating network of hydrophilic fibers and hydrophobic polymers. Unlike bilayer aerogels that separate hydrophilic and hydrophobic layers, LipClean's interpenetrating structure is precisely engineered through polymer design and gradient cross\u2010linking. This optimization enhances both bodily fluid flow and lipid adsorption while minimizing the removal of essential plasma components and ensuring unobstructed cell passage. In preclinical testing, LipClean significantly reduced triglyceride and cholesterol levels in an elderly rat model of hyperlipidemia and normalized lipid levels in blood samples from hypertensive patients. Importantly, purified blood maintained normal levels of blood cells and physiological and biochemical indicators after apheresis, highlighting LipClean's potential for managing hyperlipidemia\u2010related disorders. This study, therefore, underscores the importance of interdisciplinary collaboration in driving medical device innovation.<\/jats:p>","DOI":"10.1002\/adma.202420091","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T04:54:06Z","timestamp":1745211246000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["An Optimized Aerogel\u2010Based Apheresis Device for Targeted Lipid Clearance in Elderly Hyperlipidemia Patients"],"prefix":"10.1002","volume":"37","author":[{"given":"Hao","family":"Zheng","sequence":"first","affiliation":[{"name":"National Laboratory of Solid State Microstructures Collaborative Innovation Center of Advanced Microstructures Chemistry and Biomedicine Innovation Center ChemBioMed Interdisciplinary Research Center at Nanjing University College of Engineering and Applied Sciences Jiangsu Key Laboratory of Artificial Functional Materials Nanjing University  Nanjing 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