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While biologics have demonstrated notable success in treating some patients, there remains a critical need for alternative therapeutic strategies to address primary and secondary non\u2010responders. In this study, a dendritic cell (DC)\u2010based biohybrid immunomodulator is developed to alleviate intestinal inflammation, demonstrating remarkable efficacy in combating IBD. This biohybrid immunomodulator is engineered by conjugating resolvin E1\u2010loaded liposomes with Fas ligand (FasL)\u2010transfected DCs. Elevated Fas expression is observed in intestinal tissue samples from IBD patients, and the immunomodulator effectively reduced inflammation by selectively eliminating Fas\n                    <jats:sup>+<\/jats:sup>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells and neutrophils. The therapeutic potential of this approach is validated in both mouse and rabbit models of IBD, where it exhibites significant anti\u2010inflammatory effects. Furthermore, the immunomodulator can be manufactured using human peripheral blood mononuclear cells and bone marrow\u2010derived DCs, demonstrating a robust capacity to induce T cell apoptosis. This study presents a feasible and customizable strategy for mitigating intestinal inflammation, offering a promising advancement in the treatment of IBD.\n                  <\/jats:p>","DOI":"10.1002\/adma.202420113","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T02:36:02Z","timestamp":1750646162000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Dendritic Cell\u2010Based Biohybrid Immunomodulator Alleviates Intestinal Inflammatory Disease"],"prefix":"10.1002","volume":"37","author":[{"given":"Wenzhe","family":"Yi","sequence":"first","affiliation":[{"name":"State Key Laboratory of Drug Research &amp; Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai 201203 China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 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