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To date, there are no effective clinical drugs available to improve long\u2010term outcomes for post\u2010stroke patients. A novel nucleic acid agent circSCMH1 which can promote sensorimotor function recovery in rodent and nonhuman primate animal stroke models has been found. However, there are still delivery challenges to overcome for its clinical implementation. Besides, its effects on post\u2010stroke cognitive functions remain unexplored. Herein, lipid nanoparticle\n                    <jats:bold>circSCMH1@LNP1<\/jats:bold>\n                    is established to deliver circSCMH1 and explore its therapeutic efficacy comprehensively. Distribution experiments demonstrate that intranasal administration of\n                    <jats:bold>circSCMH1@LNP1<\/jats:bold>\n                    significantly increases circSCMH1 distribution in the peri\u2010infarct region and reduces its non\u2010specific accumulation in other organs compared to intravenous injection. Therapeutic results indicate that\n                    <jats:bold>circSCMH1@LNP1<\/jats:bold>\n                    promotes synaptic plasticity, vascular repair, neuroinflammation relief, and myelin sheath formation, thereby achieving enhanced sensorimotor and cognitive function recovery in post\u2010stroke mice. In conclusion, this research presents a simple and effective LNP system for efficient delivery of circSCMH1 via intranasal administration to repair post\u2010stroke brain injury. It is envisioned that this study may bridge a crucial gap between basic research and translational application, paving the way for clinical implementation of novel circSCMH1 in post\u2010stroke patient management.\n                  <\/jats:p>","DOI":"10.1002\/adma.202500598","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T21:41:28Z","timestamp":1743284488000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Nose\u2010to\u2010Brain Delivery of Circular RNA SCMH1\u2010Loaded Lipid Nanoparticles for Ischemic Stroke Therapy"],"prefix":"10.1002","volume":"37","author":[{"given":"Yanpeng","family":"Jia","sequence":"first","affiliation":[{"name":"Department of Pharmacology Jiangsu Provincial Key Laboratory of Critical Care Medicine School of Medicine Southeast University  87 Dingjiaqiao Road Nanjing Jiangsu 210009 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