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A biomimetic peptide\u2010modified lipid nanoparticle\u2010based sprayable hydrogel is developed to mimic and amplify the blood coagulation process for effective hemostasis. A platelet adhesion peptide (PAP, sequence: GFOGER) and platelet crosslinking peptide (PCP, sequence: GGQQLK) are customized and conjugated to 1,2\u2010distearoyl\u2010sn\u2010glycero\u20103\u2010phosphoethanolamine\u2010N[methoxy (polyethylene glycol) 2000] acid (DSPE\u2010PEG2000\u2010COOH) via amido bonds to form DSPE\u2010PEG\u2010PAP and DSPE\u2010PEG\u2010PCP, respectively. These compounds are mixed with distearoyl\u2010sn\u2010glycero\u20103\u2010phosphocholine, cholesterol, and distearoyl\u2010sn\u2010glycero\u20103\u2010phospho\u2010L\u2010serine (DSPS) to construct the peptide\u2010modified lipid nanoparticles via thin film rehydration. The nanoparticles are incorporated into a CaCl\n                    <jats:sub>2<\/jats:sub>\n                    \u2010sodium alginate sprayable hydrogel crosslinked via ionic bonds. The application of the hydrogel solution quickly gels and seals the wound. The PAP activates and adheres platelets, the DSPS and Ca\n                    <jats:sup>2+<\/jats:sup>\n                    amplify prothrombin activation, and PCP strengthens the fibrin network. The hydrogel achieves rapid hemostasis within 30 s in a liver hemorrhage model. This sprayable hydrogel has significant potential for managing non\u2010compressible hemorrhaging.\n                  <\/jats:p>","DOI":"10.1002\/adma.202500908","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T08:49:03Z","timestamp":1748335743000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["A Sprayable Hydrogel Based on Biomimetic Polypeptide\u2010Modified Lipid Nanoparticles for Treating Non\u2010Compressible Hemorrhaging"],"prefix":"10.1002","volume":"37","author":[{"given":"Yajun","family":"Feng","sequence":"first","affiliation":[{"name":"Engineering Research Center of Western Resource Innovation Medicine Green Manufacturing Ministry of Education School of Chemical Engineering Northwest University  Xi'an 710127 China"},{"name":"Shaanxi Key Laboratory of Degradable Biomedical Materials and Shaanxi R&amp;D Center of Biomaterials and Fermentation Engineering School of 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