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Despite encouraging progress in the development of heavy metal\u2010based nanoscale radiosensitizers, radiotherapy often fails to fully eradicate hypoxic tumors, leading to local recurrence or even progression to distant metastasis. In this study, a versatile biomimetic hybrid radiosensitizer is engineered by integrating the hypoxia\u2010activated prodrug banoxantrone and CeO\n                    <jats:sub>2<\/jats:sub>\n                    nanozymes into mesoporous silica\u2010coated Bi\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    nanoparticles (NPs), followed by camouflage coating with cancer\u2010cell\u2010derived membranes. Compared to naked Bi\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    NPs and free banoxantrone alone, the radiosensitization efficacy of the biomimetic NPs is substantially enhanced toward both normoxic and hypoxic cancer cells. Moreover, lung metastasis is markedly inhibited by reactive oxygen species\u2010mediated remodeling of the extracellular matrix through the activity of CeO\n                    <jats:sub>2<\/jats:sub>\n                    nanozymes. As confirmed by in vitro and in vivo results, the biomimetic hybrid radiosensitizer enhances radiotherapy against lung metastasis with fewer side effects. This study provides compelling evidence for the development of next\u2010generation radiosensitizers with optimized functionalities using biomimetic hybrid engineering to finely balance the benefits and risks of radiotherapy.\n                  <\/jats:p>","DOI":"10.1002\/adma.202501077","type":"journal-article","created":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T11:02:11Z","timestamp":1751194931000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Biomimetic Engineering of Hybrid Radiosensitizers to Boost Radiotherapy against Cancer Metastasis"],"prefix":"10.1002","volume":"37","author":[{"given":"Huandong","family":"Xiang","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences and Engineering South China University of Technology Guangzhou International Campus  Guangzhou 511442 P. R. 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