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Photo\u2010energy conversion\u2010based nanomaterials have emerged as a versatile platform that utilizes the unique properties of light to activate theranostics with high spatial and temporal precision. This review provides a comprehensive overview of recent developments in photo\u2010energy conversion using nanomaterials, highlighting their applications in disease theranostics. The discussion begins by exploring the fundamental principles of photo\u2010energy conversion in nanomaterials, including the types of materials used and various light\u2010triggered mechanisms, such as photoluminescence, photothermal, photoelectric, photoacoustic, photo\u2010triggered SERS, and photodynamic processes. Following this, the review delves into the broad spectrum of applications of photo\u2010energy conversion in nanomaterials, emphasizing their role in the diagnosis and treatment of major diseases, including cancer, neurodegenerative disorders, retinal degeneration, and osteoarthritis. 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