{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T12:21:05Z","timestamp":1792498865549,"version":"4.5.0"},"reference-count":89,"publisher":"Wiley","issue":"33","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFE0201200"],"award-info":[{"award-number":["2024YFE0201200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272003"],"award-info":[{"award-number":["82272003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371976"],"award-info":[{"award-number":["82371976"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52173133"],"award-info":[{"award-number":["52173133"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52373148"],"award-info":[{"award-number":["52373148"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52403195"],"award-info":[{"award-number":["52403195"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The chronic inflammatory milieu of rheumatoid arthritis (RA), marked by elevated reactive oxygen species (ROS), perpetually activated pro\u2010inflammatory macrophages (M1) and osteoclasts, and significant infiltration of pro\u2010inflammatory cytokines contributes to abnormal articular redox imbalance, severe synovitis, and progressive joint erosion. In this study, the rational design of a biocatalytic and redox\u2010regulated nanoarchitecture comprising Ru cluster\u2010anchored hydroxylated Fe\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    (Ru\u2010HFO) encapsulated within bone marrow stem cell\u2010derived extracellular vesicles (BEVs), for precision inflammation modulation to combat RA is proposed. When combined with ultrasound (US) stimulation, this biocatalytic and inflammation\u2010targeting nanoarchitecture (BEVs@Ru\u2010HFO) can reprogram macrophages and osteoclasts to restore redox and immune homeostasis, thereby alleviating RA. The findings reveal that the hydroxylation strategy enhances electron density at Ru redox centers and fine\u2010tunes the binding affinity of oxygen intermediates, thereby ensuring exceptional multi\u2010enzymatic ROS\u2010scavenging activities. Notably, under ultrasonic irradiation, BEVs@Ru\u2010HFO targets inflamed joints, promotes the local accumulation of anti\u2010inflammatory macrophages, downregulates inflammatory cytokines, and ameliorates the hypoxic microenvironment to inhibit osteoclastogenesis. This ultimately confers bone and cartilage protection and restores joint function. It is posit that this biocatalytic and redox\u2010regulated nanoarchitecture, with its superior antioxidant and immunomodulatory capabilities, represents a promising strategy for engineering ROS\u2010catalytic materials to treat RA and potentially many other autoimmune diseases.\n                  <\/jats:p>","DOI":"10.1002\/adma.202502147","type":"journal-article","created":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T22:10:16Z","timestamp":1748815816000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Biocatalytic and Redox\u2010Regulated Nanoarchitectures for Precision Inflammation and Immune Homeostasis Modulation to Combat Rheumatoid Arthritis"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6050-8039","authenticated-orcid":false,"given":"Sutong","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Medical Ultrasound, West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2979-4057","authenticated-orcid":false,"given":"Songya","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound, West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering, National Key Laboratory of Advanced Polymer Materials Sichuan University  Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering, National Key Laboratory of Advanced Polymer Materials Sichuan University  Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound, West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound, West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound, West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, School of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine Macau University of Science and Technology  Macao 999078 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, School of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine Macau University of Science and Technology  Macao 999078 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lang","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound, West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3328-1147","authenticated-orcid":false,"given":"Li","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound, West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6872-2240","authenticated-orcid":false,"given":"Chong","family":"Cheng","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering, National Key Laboratory of Advanced Polymer Materials Sichuan University  Chengdu 610065 China"},{"name":"Department of Endodontics, Department of Orthodontics, State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.124"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c09127"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.69"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35472-2"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-024-01687-1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202304123"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202310061"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13725"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36625-7"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-023-01523-y"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202211147"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-024-01715-0"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39745-2"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202404900"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-019-1960-x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c09472"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12712"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44222-024-00205-1"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2024.06.017"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202210144"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43586-024-00315-5"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00457A"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00718G"},{"key":"e_1_2_9_24_1","volume":"64","author":"Kotov N. A.","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-45668-3"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04243-2"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CS00087G"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-021-00609-x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-024-01259-5"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202304271"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2020.08.020"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16544-7"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202101804"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c13597"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202407644"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40010-9"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2020.105230"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jallcom.2021.163026"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcatb.2022.121825"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30166-1"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rinp.2021.105056"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202300387"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202303331"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c11448"},{"key":"e_1_2_9_45_1","first-page":"1","volume":"15","author":"Zhang S.","year":"2024","journal-title":"Nat. Commun."},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20275-0"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202400838"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26456-9"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-023-5760-5"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202404411"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-54075-7"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-023-01346-x"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202302829"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-53824-y"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-020-00466-1"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.9b03706"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33889-3"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.06.010"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111434"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-024-01801-3"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1088\/1478-3975\/12\/6\/066007"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202006169"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26052-x"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202103490"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-023-01801-z"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596\u2010024\u201001103\u2010x"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29735-1"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202412429"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.190"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202408787"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202404774"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-45072-x"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01499-0"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ade6973"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c07048"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.198"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39837"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28203-0"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c02900"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1308755110"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.173"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b08303"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-024-01759-2"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06603-5"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c09870"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2213373119"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202302503"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122943"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202307379"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202502147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T19:42:13Z","timestamp":1759779733000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202502147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":89,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/adma.202502147"],"URL":"https:\/\/doi.org\/10.1002\/adma.202502147","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2025-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2502147"}}