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By precisely fine\u2010tuning the size and shape of metal nanoparticles (NPs), such as gold nanoparticles (AuNPs), it has been possible to gain control over light interaction, modulating localized surface plasmon resonance (LSPR), a phenomenon that involves the collective oscillation of free conduction electrons. This has opened the path toward more powerful biomedical applications, including surface\u2010enhanced Raman spectroscopy (SERS) and photothermal therapy (PTT). When AuNPs dimensions fall below 2 nm, they become gold nanoclusters (AuNCs), losing the LSPR but acquitting fluorescence due to their molecule\u2010like behavior. This unique feature makes them ideal for high\u2010resolution imaging, biomarker detection, and advanced therapies. Beyond traditional uses, the recent inclusion of AuNPs into nanomotors (NMs) enhances precise in vivo tracking and targeted drug delivery. 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