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However, part of some patients will still suffer from tumor recurrence due to incomplete ablation (e.g., restricted thermal conductivity, etc.). Notably, RFA can evoke anti\u2010tumor immunity by releasing tumor\u2010associated antigens (TAAs), but this effect is weak. Herein, to boost thermal and immune therapeutic efficiency for complete tumor eradication, an effective nano\u2010adjuvant (CpG\u2010pIL12\u2010LDHs, LC12), layered double hydroxides (LDHs) carrying immune stimulators, CpG ODN (CpG) and IL\u201012 plasmid (pIL\u201012), is developed, which is further integrated into a 3D\u2010printed collar for eliciting potent thermotherapy and therapeutic vaccine against lung cancer. The as\u2010prepared 3D\u2010printed adjuvant collar (3D\u2010LC12) can be attached to the RFA electronic needle and respond to the radiofrequency electrical field during treatment, enhancing ablation temperature, area, and nano\u2010adjuvant's diffusion. After release from the temperature\u2010sensitive collar, LC12 can form an in situ therapeutic cancer vaccine, activate APCs, and remodel the tumor microenvironment (TME), triggering a robust antitumor immune response. Therefore, the current study demonstrates a multi\u2010functional 3D\u2010printed adjuvant collar for efficient eradication of lung cancer via one\u2010time RFA\u2010integrated therapy, providing a novel combined strategy for interventional thermal therapy against tumors.<\/jats:p>","DOI":"10.1002\/adma.202502375","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T06:33:31Z","timestamp":1756794811000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Synergistic 3D\u2010Printed Collar Transforms Radiofrequency Ablation Into Potent Thermal Immunotherapy for Lung Cancer"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4436-2743","authenticated-orcid":false,"given":"Weiyu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Center for Oncology Medicine the Fourth Affiliated Hospital of 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